Search for melanoma markers in plasma and serum samples

Roberta Seraglia, Susanna Vogliardi, Graziella Allegri, Stefano Comai, Mario Lise, Carlo Riccardo Rossi, Simone Mocellin, Romano Scalerta, Eugenio Ragazzi, Pietro Traldi

Research output: Contribution to journalArticlepeer-review


Fourteen blood samples from patients with melanomas and 11 blood samples from healthy subjects were analyzed by matrix-assisted laser desorption/ionization mass spectrometry. The study focussed on species of low molecular weight, in the 800-5000 Da range, present in plasma and sera. While for healthy subjects plasma samples lead to the production of a higher number of ionic species, for melanoma patients a high number of diagnostic ions, present with high frequency and with quite high relative abundance, are present, in particular, in serum samples and, to a lesser extent, also in plasma. Since plasma samples are obtained more easily in comparison to sera, it is possible to suggest that plasma can also be used for these studies.

Original languageEnglish
Pages (from-to)353-360
Number of pages8
JournalEuropean Journal of Mass Spectrometry
Issue number3
Publication statusPublished - 2005


  • Human plasma
  • Human serum
  • Mass spectrometry
  • Melanomas

ASJC Scopus subject areas

  • Spectroscopy
  • Atomic and Molecular Physics, and Optics


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