Search for poliovirus long-term excretors among patients affected by agammaglobulinemia

Lucia Fiore, Alessandro Plebani, Gabriele Buttinelli, Stefano Fiore, Valentina Donati, Jill Marturano, Annarosa Soresina, Baldassarre Martire, Chiara Azzari, Giovanni Nigro, Fabio Cardinale, Antonino Trizzino, Claudio Pignata, Patrizia Alvisi, Elisa Anastasio, Grazia Bossi, Alberto G. Ugazio

Research output: Contribution to journalArticlepeer-review


Patients with agammaglobulinemia may excrete enteroviruses, including vaccine-derived poliovirus, for prolonged periods of time. This poses a risk to the patients but it also may pose a risk to the population after eradication of poliovirus and the cessation of routine vaccination. To assess this risk, a pilot study was performed to identify potential poliovirus long-term excretors in a cohort of 38 patients with a definite/presumptive diagnosis of X-linked agammaglobulinemia (XLA). Stool samples were analyzed to detect any polio or other enteroviruses replicating in the gut and neutralizing antibodies against polioviruses were measured in the sera. No viruses were isolated from the stool samples and most sera had neutralizing antibody levels against all three poliovirus serotypes considered by the WHO to be protective in immunocompetent individuals. This suggests that long-term excretion of enteroviruses in patients with agammaglobulinemia is relatively uncommon.

Original languageEnglish
Pages (from-to)98-102
Number of pages5
JournalClinical Immunology
Issue number1
Publication statusPublished - Apr 2004


  • Immunodeficiency
  • Polio eradication
  • Poliovirus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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