Searching for IgA nephropathy candidate genes: Genetic studies combined with high throughput innovative investigations

F. P. Schena, G. Cerullo, D. D. Torres, G. Zaza, S. Cox, L. Bisceglia, F. Scolari, G. Frascà, G. M. Ghiggeri, A. Amoroso, F. Paolo Schena

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

Idiopathic IgA Nephropathy (IgAN) is the most common biopsy-proven glomerulonephritis worldwide. All races with the exception of Blacks and Indians are involved. Families with two or more relatives affected by IgAN may be observed in 15-20% of pedigrees of IgAN patients. Genome wide linkage study has been considered the most promising approach to identify IgAN susceptibility genes. Therefore, some European investigators constituted the European IgAN Consortium which was initially funded by the European Union. Data from linkage analysis studies, family association studies and case-control association studies are reported. To date, the Consortium has identified two loci (located on chromosomes 4q26-31 and 17q12-22), in addition to the previous study which described the first IgAN locus on chromosome 6q22-23. The functional mapping of genes involved in the disease proceeds from the identification of susceptibility loci identified by linkage analysis (step 1) to the isolation of candidate genes within gene disease-susceptibility loci, after obtaining information by microarray analysis carried out on peripheral leukocytes and renal tissue samples (step 2). Then, the process will proceed from the design of RNA interference-agents against selected genes (step 3) to the application of systematically tested effect of RNA agents on functional cellular assay (step 4). The above combined high-throughput technologies will give information on the pathogenic mechanisms of IgAN. In addition, these data may indicate potential targets for screening, prevention and early diagnosis of the disease and more appropriate and effective treatment.

Original languageEnglish
Title of host publicationContributions to Nephrology
Pages80-89
Number of pages10
Volume157
DOIs
Publication statusPublished - 2007

Publication series

NameContributions to Nephrology
Volume157
ISSN (Print)03025144

Fingerprint

Immunoglobulin A
Genes
Chromosomes
Chromosome Mapping
Information Storage and Retrieval
Disease Susceptibility
European Union
Pedigree
Microarray Analysis
Glomerulonephritis
RNA Interference
Case-Control Studies
Early Diagnosis
Leukocytes
Research Personnel
Genome
RNA
Technology
Kidney
Biopsy

ASJC Scopus subject areas

  • Nephrology

Cite this

Schena, F. P., Cerullo, G., Torres, D. D., Zaza, G., Cox, S., Bisceglia, L., ... Schena, F. P. (2007). Searching for IgA nephropathy candidate genes: Genetic studies combined with high throughput innovative investigations. In Contributions to Nephrology (Vol. 157, pp. 80-89). (Contributions to Nephrology; Vol. 157). https://doi.org/10.1159/0000102308

Searching for IgA nephropathy candidate genes : Genetic studies combined with high throughput innovative investigations. / Schena, F. P.; Cerullo, G.; Torres, D. D.; Zaza, G.; Cox, S.; Bisceglia, L.; Scolari, F.; Frascà, G.; Ghiggeri, G. M.; Amoroso, A.; Schena, F. Paolo.

Contributions to Nephrology. Vol. 157 2007. p. 80-89 (Contributions to Nephrology; Vol. 157).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Schena, FP, Cerullo, G, Torres, DD, Zaza, G, Cox, S, Bisceglia, L, Scolari, F, Frascà, G, Ghiggeri, GM, Amoroso, A & Schena, FP 2007, Searching for IgA nephropathy candidate genes: Genetic studies combined with high throughput innovative investigations. in Contributions to Nephrology. vol. 157, Contributions to Nephrology, vol. 157, pp. 80-89. https://doi.org/10.1159/0000102308
Schena FP, Cerullo G, Torres DD, Zaza G, Cox S, Bisceglia L et al. Searching for IgA nephropathy candidate genes: Genetic studies combined with high throughput innovative investigations. In Contributions to Nephrology. Vol. 157. 2007. p. 80-89. (Contributions to Nephrology). https://doi.org/10.1159/0000102308
Schena, F. P. ; Cerullo, G. ; Torres, D. D. ; Zaza, G. ; Cox, S. ; Bisceglia, L. ; Scolari, F. ; Frascà, G. ; Ghiggeri, G. M. ; Amoroso, A. ; Schena, F. Paolo. / Searching for IgA nephropathy candidate genes : Genetic studies combined with high throughput innovative investigations. Contributions to Nephrology. Vol. 157 2007. pp. 80-89 (Contributions to Nephrology).
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