Abstract
A linkage and association analysis was made on 14 Italian families with recurrent migraine. We analyzed five chromosomal regions surrounding the candidate genes 5HT1D (lp36.3-34.3), 5HT1B (6q13), 5HT2A (13q14-21), 5HT transporter (17q11.2-12), CACNLB1 (17q11.2-22) and FHM (19p13), using 29 DNA polymorphic markers. All two-point lod scores were negative, and the χ2 sib-pair analyses were not significant, thus indicating the probable exclusion of these regions as sites of migraine genes in our population.
Original language | English |
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Pages (from-to) | 277-282 |
Number of pages | 6 |
Journal | Neurological Sciences |
Volume | 18 |
Issue number | 5 |
Publication status | Published - 1997 |
Keywords
- Calcium channel
- Lod score
- Migraine
- Serotonin
- Sib-pair analysis
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology
- Neuroscience(all)