Searching for migraine genes: Exclusion of 290 cM out of the whole human genome

L. Monari; M. Mochi; M. L. Valentino; C. Arnaldi; P. Cortelli; A. De Monte; G. Pierangeli; G. Prologo; C. Scapoli; S. Soriani; P. Montagna

Searching for migraine genes: Exclusion of 290 cM out of the whole human genome

L. Monari, M. Mochi, M. L. Valentino, C. Arnaldi, P. Cortelli, A. De Monte, G. Pierangeli, G. Prologo, C. Scapoli, S. Soriani, P. Montagna

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

A linkage and association analysis was made on 14 Italian families with recurrent migraine. We analyzed five chromosomal regions surrounding the candidate genes 5HT_1D (lp36.3-34.3), 5HT_1B (6q13), 5HT_2A (13q14-21), 5HT transporter (17q11.2-12), CACNLB1 (17q11.2-22) and FHM (19p13), using 29 DNA polymorphic markers. All two-point lod scores were negative, and the χ2 sib-pair analyses were not significant, thus indicating the probable exclusion of these regions as sites of migraine genes in our population.

Original language	English
Pages (from-to)	277-282
Number of pages	6
Journal	Neurological Sciences
Volume	18
Issue number	5
Publication status	Published - 1997

Keywords

Calcium channel
Lod score
Migraine
Serotonin
Sib-pair analysis

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Dermatology
Neuroscience(all)

Cite this

@article{b247c8d161534e288b2550f2cfa084d0,

title = "Searching for migraine genes: Exclusion of 290 cM out of the whole human genome",

abstract = "A linkage and association analysis was made on 14 Italian families with recurrent migraine. We analyzed five chromosomal regions surrounding the candidate genes 5HT1D (lp36.3-34.3), 5HT1B (6q13), 5HT2A (13q14-21), 5HT transporter (17q11.2-12), CACNLB1 (17q11.2-22) and FHM (19p13), using 29 DNA polymorphic markers. All two-point lod scores were negative, and the χ2 sib-pair analyses were not significant, thus indicating the probable exclusion of these regions as sites of migraine genes in our population.",

keywords = "Calcium channel, Lod score, Migraine, Serotonin, Sib-pair analysis",

author = "L. Monari and M. Mochi and Valentino, {M. L.} and C. Arnaldi and P. Cortelli and {De Monte}, A. and G. Pierangeli and G. Prologo and C. Scapoli and S. Soriani and P. Montagna",

year = "1997",

language = "English",

volume = "18",

pages = "277--282",

journal = "Neurological Sciences",

issn = "1590-1874",

publisher = "Springer-Verlag Italia s.r.l.",

number = "5",

}

TY - JOUR

T1 - Searching for migraine genes

T2 - Exclusion of 290 cM out of the whole human genome

AU - Monari, L.

AU - Mochi, M.

AU - Valentino, M. L.

AU - Arnaldi, C.

AU - Cortelli, P.

AU - De Monte, A.

AU - Pierangeli, G.

AU - Prologo, G.

AU - Scapoli, C.

AU - Soriani, S.

AU - Montagna, P.

PY - 1997

Y1 - 1997

N2 - A linkage and association analysis was made on 14 Italian families with recurrent migraine. We analyzed five chromosomal regions surrounding the candidate genes 5HT1D (lp36.3-34.3), 5HT1B (6q13), 5HT2A (13q14-21), 5HT transporter (17q11.2-12), CACNLB1 (17q11.2-22) and FHM (19p13), using 29 DNA polymorphic markers. All two-point lod scores were negative, and the χ2 sib-pair analyses were not significant, thus indicating the probable exclusion of these regions as sites of migraine genes in our population.

AB - A linkage and association analysis was made on 14 Italian families with recurrent migraine. We analyzed five chromosomal regions surrounding the candidate genes 5HT1D (lp36.3-34.3), 5HT1B (6q13), 5HT2A (13q14-21), 5HT transporter (17q11.2-12), CACNLB1 (17q11.2-22) and FHM (19p13), using 29 DNA polymorphic markers. All two-point lod scores were negative, and the χ2 sib-pair analyses were not significant, thus indicating the probable exclusion of these regions as sites of migraine genes in our population.

KW - Calcium channel

KW - Lod score

KW - Migraine

KW - Serotonin

KW - Sib-pair analysis

UR - http://www.scopus.com/inward/record.url?scp=0031243757&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031243757&partnerID=8YFLogxK

M3 - Article

C2 - 9412851

AN - SCOPUS:0031243757

VL - 18

SP - 277

EP - 282

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - 5

ER -

Searching for migraine genes: Exclusion of 290 cM out of the whole human genome

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this