Searching for migraine genes: Exclusion of 290 cM out of the whole human genome

L. Monari, M. Mochi, M. L. Valentino, C. Arnaldi, P. Cortelli, A. De Monte, G. Pierangeli, G. Prologo, C. Scapoli, S. Soriani, P. Montagna

Research output: Contribution to journalArticlepeer-review

Abstract

A linkage and association analysis was made on 14 Italian families with recurrent migraine. We analyzed five chromosomal regions surrounding the candidate genes 5HT1D (lp36.3-34.3), 5HT1B (6q13), 5HT2A (13q14-21), 5HT transporter (17q11.2-12), CACNLB1 (17q11.2-22) and FHM (19p13), using 29 DNA polymorphic markers. All two-point lod scores were negative, and the χ2 sib-pair analyses were not significant, thus indicating the probable exclusion of these regions as sites of migraine genes in our population.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalNeurological Sciences
Volume18
Issue number5
Publication statusPublished - 1997

Keywords

  • Calcium channel
  • Lod score
  • Migraine
  • Serotonin
  • Sib-pair analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology
  • Neuroscience(all)

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