Searching for psoriasis susceptibility genes in Italy: Genome scan and evidence for a new locus on chromosome 1

Francesca Capon, Giuseppe Novelli, Sabrina Semprini, Maurizio Clementi, Maurizio Nudo, Pietro Vultaggio, Cinzia Mazzanti, Tommaso Gobello, Annalisa Botta, Giuseppe Fabrizi, Bruno Dallapiccola

Research output: Contribution to journalArticle

Abstract

Psoriasis is a chronic inflammatory dermatitis, affecting ≃2% of the population, Major clinical features include red, scaly patches on scalp, elbows, and knees, with or without severe arthritis. Several putative susceptibility loci have been mapped by parametric and non-parametric linkage analysis to chromosome regions 2p, 4q, 6p, 8q, 16q, 17q, and 20p; however, the most significant results and confirmation of linkage are only available for the 17q and 6p chromosome regions at present. In this study, 22 multiplex Italian families were investigated for linkage to 6p and 17q susceptibility regions, using a set of four microsatellites. These analyses failed to detect significant linkage with any of the examined markers. A genome-wide scan was then performed on one of the largest pedigrees, searching for an additional susceptibility locus. This study disclosed a putative linkage to chromosome 1cen-q21 markers. When these microsatellites were analyzed in the remaining families of the sample, a significant linkage was observed using both parametric and non-parametric methods. The highest two-point lod score value was obtained with D1S305 marker (3.75 at θ = 0.05). Non-parametric analysis at this locus also demonstrated a significant excess of allele sharing (p = 0.0001).

Original languageEnglish
Pages (from-to)32-35
Number of pages4
JournalJournal of Investigative Dermatology
Volume112
Issue number1
DOIs
Publication statusPublished - 1999

Keywords

  • Genome scanning
  • Linkage
  • Multigenic disorder
  • Psoriasin

ASJC Scopus subject areas

  • Dermatology

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