Seasonal and monthly variability in the incidence of venous thromboembolism: A systematic review and a meta-analysis of the literature

Francesco Dentali, Walter Ageno, Elena Rancan, Alberto V. Donati, Luca Galli, Alessandro Squizzato, Achille Venco, Pier Mannuccio Mannucci, Roberto Manfredini

Research output: Contribution to journalArticle

Abstract

Many studies showed that the occurrence of cardiovascular and cerebrovascular events exhibits a seasonal and monthly variation. Evidences of a seasonal and monthly variation in the incidence of venous thromboembolism (VTE) are more conflicting. We conducted a systematic review and a meta-analysis of the literature to assess the presence of an infradian rhythm of this disease. MEDLINE and EMBASE databases were searched up to January 2010. Monthly and seasonal variation in the incidence of VTE were analysed. We included studies analysing seasonal or monthly aggregation in the incidence of deep-vein thrombosis (DVT) and/or pulmonary embolism (PE) with an objective diagnosis of VTE. Two authors independently reviewed and extracted data. Seventeen studies for a total of about 35,000 patients were included. Twelve studies analysed the seasonal variation and 10 studies the monthly variation of VTE. Our results showed a significantly increased incidence of VTE in winter (chi-square 146.04, p

Original languageEnglish
Pages (from-to)439-447
Number of pages9
JournalThrombosis and Haemostasis
Volume106
Issue number3
DOIs
Publication statusPublished - 2011

Keywords

  • Monthly
  • Seasonal
  • Venous thromboembolism

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Seasonal and monthly variability in the incidence of venous thromboembolism: A systematic review and a meta-analysis of the literature'. Together they form a unique fingerprint.

  • Cite this