Sebaceoma arising in association with seborrheic keratosis

Roberto Betti, Elena Inselvini, Raffaella Vergani, Laura Moneghini, Carlo Crosti

Research output: Contribution to journalArticlepeer-review


We report a case of a 60-year-old woman with a 4-year history of an asymptomatic plaque on her left cheek. The lesion was composed of two distinct adjacent and continuous parts comprising a lateral yellowish flat portion and a medial reddish nodular portion. Histologic examination revealed that the plaque was composed of two different adjacent tumors. The lateral portion of the plaque had the aspect of a seborrheic keratosis (SK) with hyperkeratosis and acanthosis with irregular proliferation of apparently benign basaloid and squamous keratinocytes and small horn pseudocysts. The medial portion showed a dermal tumor made up of differently sized lobules composed of immature sebocytes mixed with single or clustered mature sebaceous cells. Sebaceous ductal differentiation was visible. We made the diagnosis of SK associated with sebaceoma. The association of an SK with a benign neoplasm with sebaceous differentiation is rare. It may only be a coincidence, but a role for the preexisting SK cannot be ruled out.

Original languageEnglish
Pages (from-to)58-61
Number of pages4
JournalAmerican Journal of Dermatopathology
Issue number1
Publication statusPublished - 2001


  • Collision tumor
  • Sebaceoma
  • Seborrheic keratosis

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine


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