Abstract
Original language | English |
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Journal | Am. J. Hematol. |
DOIs | |
Publication status | E-pub ahead of print - Dec 9 2019 |
Keywords
- acetylsalicylic acid
- hydroxyurea
- interferon
- pipobroman
- ruxolitinib
- acute leukemia
- age
- aged
- anemia
- Article
- basal cell carcinoma
- breast cancer
- cancer diagnosis
- cancer prognosis
- cancer recurrence
- cancer survival
- case control study
- cause of death
- controlled study
- digestive system metastasis
- drug exposure
- esophagus metastasis
- female
- head and neck metastasis
- human
- liver metastasis
- lung metastasis
- lymphoma
- major clinical study
- male
- metastasis
- mortality rate
- multiple myeloma
- myeloproliferative neoplasm
- nervous system metastasis
- osteosarcoma
- ovary metastasis
- pancreas metastasis
- prediction
- priority journal
- prostate cancer
- survival analysis
- thrombosis
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Second cancers in MPN: Survival analysis from an international study : American Journal of Hematology. / Marchetti, M.; Ghirardi, A.; Masciulli, A.; Carobbio, A.; Palandri, F.; Vianelli, N.; Rossi, E.; Betti, S.; Di Veroli, A.; Iurlo, A.; Cattaneo, D.; Finazzi, G.; Bonifacio, M.; Scaffidi, L.; Patriarca, A.; Rumi, E.; Casetti, I.C.; Stephenson, C.; Guglielmelli, P.; Elli, E.M.; Palova, M.; Rapezzi, D.; Erez, D.; Gomez, M.; Wille, K.; Perez-Encinas, M.; Lunghi, F.; Angona, A.; Fox, M.L.; Beggiato, E.; Benevolo, G.; Carli, G.; Cacciola, R.; McMullin, M.F.; Tieghi, A.; Recasens, V.; Isfort, S.; Pane, F.; De Stefano, V.; Griesshammer, M.; Alvarez-Larran, A.; Vannucchi, A.M.; Rambaldi, A.; Barbui, T.
In: Am. J. Hematol., 09.12.2019.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Second cancers in MPN: Survival analysis from an international study
T2 - American Journal of Hematology
AU - Marchetti, M.
AU - Ghirardi, A.
AU - Masciulli, A.
AU - Carobbio, A.
AU - Palandri, F.
AU - Vianelli, N.
AU - Rossi, E.
AU - Betti, S.
AU - Di Veroli, A.
AU - Iurlo, A.
AU - Cattaneo, D.
AU - Finazzi, G.
AU - Bonifacio, M.
AU - Scaffidi, L.
AU - Patriarca, A.
AU - Rumi, E.
AU - Casetti, I.C.
AU - Stephenson, C.
AU - Guglielmelli, P.
AU - Elli, E.M.
AU - Palova, M.
AU - Rapezzi, D.
AU - Erez, D.
AU - Gomez, M.
AU - Wille, K.
AU - Perez-Encinas, M.
AU - Lunghi, F.
AU - Angona, A.
AU - Fox, M.L.
AU - Beggiato, E.
AU - Benevolo, G.
AU - Carli, G.
AU - Cacciola, R.
AU - McMullin, M.F.
AU - Tieghi, A.
AU - Recasens, V.
AU - Isfort, S.
AU - Pane, F.
AU - De Stefano, V.
AU - Griesshammer, M.
AU - Alvarez-Larran, A.
AU - Vannucchi, A.M.
AU - Rambaldi, A.
AU - Barbui, T.
N1 - Cited By :1 Export Date: 24 February 2020 CODEN: AJHED Correspondence Address: Barbui, T.; FROM Research Foundation, Papa Giovanni XXIII HospitalItaly; email: tbarbui@fondazionefrom.it Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; hydroxyurea, 127-07-1; pipobroman, 54-91-1; ruxolitinib, 1092939-17-7, 941678-49-5 Funding details: Associazione Italiana per la Ricerca sul Cancro, AIRC, 5perMille Funding details: Novartis Funding text 1: This study was supported by the FROM Research Foundation, Papa Giovanni XXIII Hospital, Bergamo, Italy. The study was also supported by Associazione Italiana per la Ricerca sul Cancro, grant 5perMille, progetto MYNERVA, to PG and AMV. Funding text 2: TB has been a speaker and consultant for Novartis and he has received research grant from AOP Orphan. VDS has received consulting and lecture fees from Amgen, Celgene, Novartis, and institutional research grants from Bayer and Novartis. MLF has been a member of advisory board for Novartis and she has received travel grants from the company. MFM has been a speaker and consultant for Novartis. MM has received honoraria for advisory boards and lectures at sponsored meetings from Celgene, Amgen, Janssen, Gilead, Novartis. AMV has been a speaker for Novartis, Celgene, and Shire and participated to advisory boards of Celgene, Incyte, Novartis. The remaining authors declare that they have no conflict of interest. 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PY - 2019/12/9
Y1 - 2019/12/9
N2 - One out of ten patients with Philadelphia-negative myeloproliferative neoplasms (MPN) develop a second cancer (SC): in such patients we aimed at assessing the survival impact of SC itself and of MPN-specific therapies. Data were therefore extracted from an international nested case-control study, recruiting 798 patients with SC diagnosed concurrently or after the MPN. Overall, 2995 person-years (PYs) were accumulated and mortality rate (MR) since SC diagnosis was 5.9 (5.1-6.9) deaths for every 100 PYs. A “poor prognosis” SC (stomach, esophagus, liver, pancreas, lung, ovary, head-and-neck or nervous system, osteosarcomas, multiple myeloma, aggressive lymphoma, acute leukemia) was reported in 26.3% of the patients and was the cause of death in 65% of them (MR 11.0/100 PYs). In contrast, patients with a “non-poor prognosis” SC (NPPSC) incurred a MR of 4.6/100 PYs: 31% of the deaths were attributed to SC and 15% to MPN evolution. At multivariable analysis, death after SC diagnosis was independently predicted (HR and 95% CI) by patient age greater than 70 years (2.68; 1.88-3.81), the SC prognostic group (2.57; 1.86-3.55), SC relapse (1.53; 10.6-2.21), MPN evolution (2.72; 1.84-4.02), anemia at SC diagnosis (2.32; 1.49-3.59), exposure to hydroxyurea (1.89; 1.26-2.85) and to ruxolitinib (3.63; 1.97-6.71). Aspirin was protective for patients with a NPPSC (0.60; 0.38-0.95). In conclusion, SC is a relevant cause of death competing with MPN evolution. Prospective data are awaited to confirm the role of cytoreductive and anti-platelet drugs in modulating patient survival after the occurrence of a SC. © 2019 Wiley Periodicals, Inc.
AB - One out of ten patients with Philadelphia-negative myeloproliferative neoplasms (MPN) develop a second cancer (SC): in such patients we aimed at assessing the survival impact of SC itself and of MPN-specific therapies. Data were therefore extracted from an international nested case-control study, recruiting 798 patients with SC diagnosed concurrently or after the MPN. Overall, 2995 person-years (PYs) were accumulated and mortality rate (MR) since SC diagnosis was 5.9 (5.1-6.9) deaths for every 100 PYs. A “poor prognosis” SC (stomach, esophagus, liver, pancreas, lung, ovary, head-and-neck or nervous system, osteosarcomas, multiple myeloma, aggressive lymphoma, acute leukemia) was reported in 26.3% of the patients and was the cause of death in 65% of them (MR 11.0/100 PYs). In contrast, patients with a “non-poor prognosis” SC (NPPSC) incurred a MR of 4.6/100 PYs: 31% of the deaths were attributed to SC and 15% to MPN evolution. At multivariable analysis, death after SC diagnosis was independently predicted (HR and 95% CI) by patient age greater than 70 years (2.68; 1.88-3.81), the SC prognostic group (2.57; 1.86-3.55), SC relapse (1.53; 10.6-2.21), MPN evolution (2.72; 1.84-4.02), anemia at SC diagnosis (2.32; 1.49-3.59), exposure to hydroxyurea (1.89; 1.26-2.85) and to ruxolitinib (3.63; 1.97-6.71). Aspirin was protective for patients with a NPPSC (0.60; 0.38-0.95). In conclusion, SC is a relevant cause of death competing with MPN evolution. Prospective data are awaited to confirm the role of cytoreductive and anti-platelet drugs in modulating patient survival after the occurrence of a SC. © 2019 Wiley Periodicals, Inc.
KW - acetylsalicylic acid
KW - hydroxyurea
KW - interferon
KW - pipobroman
KW - ruxolitinib
KW - acute leukemia
KW - age
KW - aged
KW - anemia
KW - Article
KW - basal cell carcinoma
KW - breast cancer
KW - cancer diagnosis
KW - cancer prognosis
KW - cancer recurrence
KW - cancer survival
KW - case control study
KW - cause of death
KW - controlled study
KW - digestive system metastasis
KW - drug exposure
KW - esophagus metastasis
KW - female
KW - head and neck metastasis
KW - human
KW - liver metastasis
KW - lung metastasis
KW - lymphoma
KW - major clinical study
KW - male
KW - metastasis
KW - mortality rate
KW - multiple myeloma
KW - myeloproliferative neoplasm
KW - nervous system metastasis
KW - osteosarcoma
KW - ovary metastasis
KW - pancreas metastasis
KW - prediction
KW - priority journal
KW - prostate cancer
KW - survival analysis
KW - thrombosis
U2 - 10.1002/ajh.25700
DO - 10.1002/ajh.25700
M3 - Article
JO - Am. J. Hematol.
JF - Am. J. Hematol.
SN - 0361-8609
ER -