Second-hand smoke exposure in adulthood and lower respiratory health during 20 year follow up in the European Community Respiratory Health Survey 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology 11 Medical and Health Sciences 1117 Public Health and Health Services

Claudia Flexeder, Jan Paul Zock, Deborah Jarvis, Giuseppe Verlato, Mario Olivieri, Geza Benke, Michael J. Abramson, Torben Sigsgaard, Cecilie Svanes, Kjell Torén, Dennis Nowak, Rain Jõgi, Jesús Martinez-Moratalla, Pascal Demoly, Christer Janson, Thorarinn Gislason, Roberto Bono, Mathias Holm, Karl A. Franklin, Judith Garcia-AymerichValérie Siroux, Bénédicte Leynaert, Sandra Dorado Arenas, Angelo Guido Corsico, Antonio Pereira-Vega, Nicole Probst-Hensch, Isabel Urrutia Landa, Holger Schulz, Joachim Heinrich

Research output: Contribution to journalArticle

Abstract

Background: Early life exposure to tobacco smoke has been extensively studied but the role of second-hand smoke (SHS) for new-onset respiratory symptoms and lung function decline in adulthood has not been widely investigated in longitudinal studies. Our aim is to investigate the associations of exposure to SHS in adults with respiratory symptoms, respiratory conditions and lung function over 20 years. Methods: We used information from 3011 adults from 26 centres in 12 countries who participated in the European Community Respiratory Health Surveys I-III and were never or former smokers at all three surveys. Associations of SHS exposure with respiratory health (asthma symptom score, asthma, chronic bronchitis, COPD) were analysed using generalised linear mixed-effects models adjusted for confounding factors (including sex, age, smoking status, socioeconomic status and allergic sensitisation). Linear mixed-effects models with additional adjustment for height were used to assess the relationships between SHS exposure and lung function levels and decline. Results: Reported exposure to SHS decreased in all 26 study centres over time. The prevalence of SHS exposure was 38.7% at baseline (1990-1994) and 7.1% after the 20-year follow-up (2008-2011). On average 2.4% of the study participants were not exposed at the first, but were exposed at the third examination. An increase in SHS exposure over time was associated with doctor-diagnosed asthma (odds ratio (OR): 2.7; 95% confidence interval (95%-CI): 1.2-5.9), chronic bronchitis (OR: 4.8; 95%-CI: 1.6-15.0), asthma symptom score (count ratio (CR): 1.9; 95%-CI: 1.2-2.9) and dyspnoea (OR: 2.7; 95%-CI: 1.1-6.7) compared to never exposed to SHS. Associations between increase in SHS exposure and incidence of COPD (OR: 2.0; 95%-CI: 0.6-6.0) or lung function (β: - 49 ml; 95%-CI: -132, 35 for FEV 1 and β: - 62 ml; 95%-CI: -165, 40 for FVC) were not apparent. Conclusion: Exposure to second-hand smoke may lead to respiratory symptoms, but this is not accompanied by lung function changes.

Original languageEnglish
Article number33
JournalRespiratory Research
Volume20
Issue number1
DOIs
Publication statusPublished - Feb 14 2019

Keywords

  • Adults
  • Asthma
  • Bronchitis
  • ECRHS
  • Lung function
  • Respiratory symptoms
  • Smoking

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Flexeder, C., Zock, J. P., Jarvis, D., Verlato, G., Olivieri, M., Benke, G., Abramson, M. J., Sigsgaard, T., Svanes, C., Torén, K., Nowak, D., Jõgi, R., Martinez-Moratalla, J., Demoly, P., Janson, C., Gislason, T., Bono, R., Holm, M., Franklin, K. A., ... Heinrich, J. (2019). Second-hand smoke exposure in adulthood and lower respiratory health during 20 year follow up in the European Community Respiratory Health Survey 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology 11 Medical and Health Sciences 1117 Public Health and Health Services. Respiratory Research, 20(1), [33]. https://doi.org/10.1186/s12931-019-0996-z