Second-line cabozantinib versus nivolumab in advanced renal cell carcinoma: Systematic review and indirect treatment comparison

Camillo Porta, Cezary Szczylik, Roman Casciano, Shuai Fu, Billy Amzal, Johanna Lister, Helene Karcher, Jie Meng, Monika Neumann, Jerome Dinet

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Nivolumab and cabozantinib, two new treatment options for previously-treated advanced/metastatic renal cell carcinoma (aRCC), have recently been approved. METHODS: Two independent reviewers performed study selection, data extraction, and risk of bias assessment. Indirect treatment comparisons were carried out by directly assessing HR differences and statistical modeling of Kaplan-Meier curves from these two trials. RESULTS: Publications identified showed that no head-to-head comparisons had been carried out. Two indirect treatment comparisons used agreed that there was no significant difference in OS between cabozantinib and nivolumab and that cabozantinib significantly improved PFS compared to nivolumab. CONCLUSIONS: The field of aRCC treatments is evolving rapidly, creating opportunities for individualized treatments and challenges for clinicians to keep up with the evidence. In lieu of availability of direct comparisons of all options, advanced modeling results presented herein can help to inform and improve personalized treatments.
Original languageEnglish
Pages (from-to)143-148
Number of pages6
JournalCritical Reviews in Oncology/Hematology
Volume139
DOIs
Publication statusPublished - Jul 2019

Keywords

  • Advanced modeling
  • Individualized cancer therapy
  • Treatment algorithm
  • Anilides/*therapeutic use
  • Antineoplastic Agents, Immunological/*therapeutic use
  • Carcinoma, Renal Cell/*drug therapy/pathology
  • Humans
  • Kidney Neoplasms/*drug therapy/pathology
  • Nivolumab/*therapeutic use
  • Pyridines/*therapeutic use
  • Treatment Outcome

Fingerprint Dive into the research topics of 'Second-line cabozantinib versus nivolumab in advanced renal cell carcinoma: Systematic review and indirect treatment comparison'. Together they form a unique fingerprint.

  • Cite this