Second-line eribulin in triple negative metastatic breast cancer patients. Multicentre retrospective study: The TETRIS trial

Eriseld Krasniqi, Laura Pizzuti, Maria Rosaria Valerio, Elisabetta Capomolla, Claudio Botti, Giuseppe Sanguineti, Paolo Marchetti, Elisabetta Anselmi, Silverio Tomao, Antonio Giordano, Corrado Ficorella, Katia Cannita, Lorenzo Livi, Icro Meattini, Maria Mauri, Filippo Greco, Enzo Maria Veltri, Andrea Michelotti, Luca Moscetti, Francesco GiottaVito Lorusso, Ida Paris, Federica Tomao, Daniele Santini, Giuseppe Tonini, Alice Villa, Vittorio Gebbia, Teresa Gamucci, Gennaro Ciliberto, Isabella Sperduti, Marco Mazzotta, Maddalena Barba, Patrizia Vici

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Large and consistent evidence supports the use of eribulin mesylate in clinical practice in third or later line treatment of metastatic triple negative breast cancer (mTNBC). Conversely, there is paucity of data on eribulin efficacy in second line treatment. Methods: We investigated outcomes of 44 mTNBC patients treated from 2013 through 2019 with second line eribulin mesylate in a multicentre retrospective study involving 14 Italian oncologic centres. Results: Median age was 51 years, with 11.4% of these patients being metastatic at diagnosis. Median overall survival (OS) and progression free survival (PFS) from eribulin starting were 11.9 (95%CI: 8.4-15.5) and 3.5 months (95%CI: 1.7-5.3), respectively. We observed 8 (18.2%) partial responses and 10 (22.7%) patients had stable disease as best response. A longer PFS on previous first line treatment predicted a better OS (HR=0.87, 95%CI: 0.77-0.99, p= 0.038) and a longer PFS on eribulin treatment (HR=0.92, 95%CI: 0.85-0.98, p=0.018). Progression free survival to eribulin was also favorably influenced by prior adjuvant chemotherapy (HR=0.44, 95%CI: 0.22-0.88, p=0.02). Eribulin was generally well tolerated, with grade 3-4 adverse events being recorded in 15.9% of patients. Conclusions: The outcomes described for our cohort are consistent with those reported in the pivotal Study301 and subsequent observational studies. Further data from adequately-sized, ad hoc trials on eribulin use in second line for mTNBC are warranted to confirm our findings.

Original languageEnglish
Pages (from-to)2245-2250
Number of pages6
JournalInternational Journal of Medical Sciences
Volume18
Issue number10
DOIs
Publication statusPublished - Mar 27 2021

Keywords

  • Chemotherapy
  • Efficacy outcomes
  • Eribulin mesylate
  • Toxicity outcomes
  • Triple negative metastatic breast cancer

ASJC Scopus subject areas

  • Medicine(all)

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