Second line systemic therapies for hepatocellular carcinoma: Reasons for the failure

Marcello Maida, Massimo Iavarone, Maurizio Raineri, Calogero Cammà, Giuseppe Cabibbo

Research output: Contribution to journalArticlepeer-review


Hepatocellular carcinoma (HCC) is the main cause of death in patients with cirrhosis, with an increasing incidence worldwide. Sorafenib is the choice therapy for advanced HCC. Over time several randomized phase ? trials have been performed testing sunitinib, brivanib, linifanib and other molecules in head-tohead comparison with Sorafenib as first-line treatment for advanced-stage HCC, but none of these has so far been registered in this setting. Moreover, another feared vacuum arises from the absence of molecules registered as second-line therapy for patients who have failed Sorafenib, representing an urgent unmet medical need. To date all molecules tested as second-line therapies for advanced hepatocellular carcinoma, failed to demonstrate an increased survival compared to placebo. What are the possible reasons for the failure? What we should expect in the near future?

Original languageEnglish
Pages (from-to)2053-2057
Number of pages5
JournalWorld Journal of Hepatology
Issue number17
Publication statusPublished - 2015


  • Barcelona clinic liver cancer
  • Hepatocellular carcinoma
  • Sorafenib
  • Systemic therapies

ASJC Scopus subject areas

  • Hepatology


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