Second malignancies following breast cancer treatment: A case-control study based on the Peridose methodology. ALLEGRO project (task 5.4)

Roberto Orecchia, Barbara A. Jereczek-Fossa, Elena Rondi, Isa Bossi-Zanetti, Ilaria Meaglia, Rosa Luraschi, Maria Cristina Leonardi, Nicole Rotmensz, Edoardo Botteri, Cristiana Fodor, Agnese Cecconi, Anna Morra, Roberta Lazzari, Annamaria Ferrari, Federica Cattani, Viviana Galimberti, Alberto Luini, Paolo Veronesi, Stefano Zurrida, Stefano MagriniWolfgang Doerr, Nicole Humble, Klaus R. Trott, Andrea Ottolenghi, Vere Smyth, Umberto Veronesi

Research output: Contribution to journalArticlepeer-review

Abstract

Aims and background. To calculate peripheral radiation dose to the second primary site in patients who have developed a second malignancy after breast cancer radiotherapy (index cases) and to compare it with dose in the analogous anatomical site in radiotherapy-treated breast cancer patients who did not experience a second malignancy (controls). To evaluate the feasibility of Peridose-software peripheral dose calculation in retrospective case-control studies. Material and study design. A case-control study on 12,630 patients who underwent adjuvant breast radiotherapy was performed. Minimum 5-year follow-up was required. Each index case was matched with 5 controls by 1) year of birth, 2) year of radiotherapy and 3) follow-up duration. Peridose-software was used to calculate peripheral dose. Results. 195 second cancers were registered (0.019% of all patients treated with adjuvant irradiation). Several methodological limitations of the Peridose calculation were encountered including impossibility to calculate the peripheral dose in the patients treated with intraoperative or external electron beam radiotherapy, in case of second tumors located at

Original languageEnglish
Pages (from-to)715-721
Number of pages7
JournalTumori
Volume98
Issue number6
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Breast cancer radiotherapy
  • Peridose
  • Peripheral dose
  • Second primary tumors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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