Second Malignancies in Children Following Treatment for Neuroblastoma

Alberto Garaventa, Bruno De Bernardi

Research output: Chapter in Book/Report/Conference proceedingChapter


On the basis of currently available information, the cumulative incidence of second malignant neoplasm (SMN) for neuroblastoma patients is approximately 2% at 20 years from the initial diagnosis. The most commonly observed SMNs include thyroid carcinomas, osteogenic and soft tissue sarcomas, breast and colon carcinomas, acute myeloid and lymphoid leukemias, Hodgkin's and non-Hodgkin's lymphomas, and brain tumors. Female survivors of neuroblastoma seem to be at higher risk of developing an SMN than males. Other predisposing factors include young age at the time of diagnosis of the first cancer, radiotherapy associated with chemotherapy, high-doses of alkylating agents and administration of topo-isomerase II inhibitors, as well as high cumulative doses and protracted schedules of epipodophyllotoxins. Longer and more targeted surveillance should be recommended including specific cancer screening at younger ages compared to the general population. Risk adapted and response-related regimens should be applied to these patients in an effort to decrease SMNs.

Original languageEnglish
Title of host publicationBrain Metastases from Primary Tumors: Epidemiology, Biology, and Therapy
PublisherElsevier Inc.
Number of pages14
ISBN (Print)9780128008966
Publication statusPublished - Apr 2014


  • Children
  • Genetic aberrations
  • Neuroblastoma
  • Second malignancy
  • Survival
  • Treatment

ASJC Scopus subject areas

  • Neuroscience(all)


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