Second non-breast primary cancer following adjuvant therapy for early breast cancer: A report from the International Breast Cancer Study Group

Lorenzo Gianni, Shari Gelber, Alberto Ravaioli, Karen N. Price, Ilaria Panzini, Manuela Fantini, Monica Castiglione-Gertsch, Olivia Pagani, Edda Simoncini, Richard D. Gelber, Alan S. Coates, Aron Goldhirsch

Research output: Contribution to journalArticle

Abstract

The incidence of second non-breast primary cancer following adjuvant treatment was evaluated using data from patients enrolled from 1978 to 1999 in four International Breast Cancer Study Group (IBCSG) trials. The occurrence of these tumours as sites of the first failure was assessed separately for two treatment comparisons: toremifene versus tamoxifen for 5 years in 1035 patients in IBCSG Trials 12-93 and 14-93 with a median follow-up of 8 years and endocrine therapy (toremifene or tamoxifen) versus chemo-endocrine therapy (CMF or AC plus toremifene or tamoxifen) in 1731 patients from IBCSG Trials III, VII and 12-93, with a combined median follow-up of 14 years. No significant differences in second non-breast primary tumours were observed in either comparison. In particular, the incidences of second primary uterine tumours with toremifene and tamoxifen were similar and no significant increase of secondary leukaemias was observed with chemo-endocrine therapy compared with endocrine therapy.

Original languageEnglish
Pages (from-to)561-571
Number of pages11
JournalEuropean Journal of Cancer
Volume45
Issue number4
DOIs
Publication statusPublished - Mar 2009

Keywords

  • Breast cancer
  • Chemotherapy
  • Endocrine therapy
  • Second primary cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Gianni, L., Gelber, S., Ravaioli, A., Price, K. N., Panzini, I., Fantini, M., Castiglione-Gertsch, M., Pagani, O., Simoncini, E., Gelber, R. D., Coates, A. S., & Goldhirsch, A. (2009). Second non-breast primary cancer following adjuvant therapy for early breast cancer: A report from the International Breast Cancer Study Group. European Journal of Cancer, 45(4), 561-571. https://doi.org/10.1016/j.ejca.2008.10.011