Second primary malignancies in patients with non-melanoma skin cancer: Results from a cancer registry–based study in Emilia Romagna, north-east Italy

Alessandro Borghi, Monica Corazza, Giorgio Chiaranda, Maria Michiara, Lucia Mangone, Bianca Caruso, Fabio Falcini, Iva Maestri, Stefano Ferretti

Research output: Contribution to journalArticle

Abstract

Background: previous research on the risk of subsequent, primary non-cutaneous malignancies among patients with non-melanoma skin cancers (NMSCs) led to conflicting results. We aimed to investigate a possible link between NMSC and second primary malignancies by using the population-based data available in cancer registries. Methods: this observational study retrospectively assessed the risk of occurrence of both synchronous and methachronous second primary tumours in a cohort of cancer patients whose first diagnosis was NMSC. The cohort came from the network of general cancer registries of the Emilia-Romagna Region, northeast Italy, in the period between 1978 and 2012, and was compared with the general population living in the same area. Two main indexes were used: i) Standardized Incidence Ratio (SIR), calculated as the ratio between the observed and the expected number of second cancers and ii) Excess Absolute Risk (EAR), expressing the absolute excess or deficit of second cancer incidence. Results: in the period analysed (1978–2012, 72,503,157 person/years, PYs), 89,912 primary NMSC were found in 76,414 patients. Among them, 14,195 developed a second primary cancer in the subsequent 501,763 follow-up PYs. NMSC patients showed an overall SIR of 1.22 (CI 95% 1.20-1,24) and an EAR of 5.11 cases/1000 PYs (CI 95% 4.48–5.74). Conclusions: the study results showed that NMSC patients had an increase in relative risk and, at least for some tumours, in absolute risk of developing a second cancer when compared with the general population. Genetic, environmental and personal risk factors may influence this finding.

Original languageEnglish
Pages (from-to)176-184
Number of pages9
JournalCancer Epidemiology
Volume61
DOIs
Publication statusPublished - Aug 1 2019

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Second Primary Neoplasms
Skin Neoplasms
Italy
Neoplasms
Registries
Incidence
Population
Observational Studies
Research

Keywords

  • Cancer registry
  • Cancer survivors
  • Excess absolute risk
  • Non-melanoma skin cancers
  • Standardized incidence ratio
  • Subsequent primary malignancies

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Cancer Research

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Second primary malignancies in patients with non-melanoma skin cancer : Results from a cancer registry–based study in Emilia Romagna, north-east Italy. / Borghi, Alessandro; Corazza, Monica; Chiaranda, Giorgio; Michiara, Maria; Mangone, Lucia; Caruso, Bianca; Falcini, Fabio; Maestri, Iva; Ferretti, Stefano.

In: Cancer Epidemiology, Vol. 61, 01.08.2019, p. 176-184.

Research output: Contribution to journalArticle

Borghi, Alessandro ; Corazza, Monica ; Chiaranda, Giorgio ; Michiara, Maria ; Mangone, Lucia ; Caruso, Bianca ; Falcini, Fabio ; Maestri, Iva ; Ferretti, Stefano. / Second primary malignancies in patients with non-melanoma skin cancer : Results from a cancer registry–based study in Emilia Romagna, north-east Italy. In: Cancer Epidemiology. 2019 ; Vol. 61. pp. 176-184.
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abstract = "Background: previous research on the risk of subsequent, primary non-cutaneous malignancies among patients with non-melanoma skin cancers (NMSCs) led to conflicting results. We aimed to investigate a possible link between NMSC and second primary malignancies by using the population-based data available in cancer registries. Methods: this observational study retrospectively assessed the risk of occurrence of both synchronous and methachronous second primary tumours in a cohort of cancer patients whose first diagnosis was NMSC. The cohort came from the network of general cancer registries of the Emilia-Romagna Region, northeast Italy, in the period between 1978 and 2012, and was compared with the general population living in the same area. Two main indexes were used: i) Standardized Incidence Ratio (SIR), calculated as the ratio between the observed and the expected number of second cancers and ii) Excess Absolute Risk (EAR), expressing the absolute excess or deficit of second cancer incidence. Results: in the period analysed (1978–2012, 72,503,157 person/years, PYs), 89,912 primary NMSC were found in 76,414 patients. Among them, 14,195 developed a second primary cancer in the subsequent 501,763 follow-up PYs. NMSC patients showed an overall SIR of 1.22 (CI 95{\%} 1.20-1,24) and an EAR of 5.11 cases/1000 PYs (CI 95{\%} 4.48–5.74). Conclusions: the study results showed that NMSC patients had an increase in relative risk and, at least for some tumours, in absolute risk of developing a second cancer when compared with the general population. Genetic, environmental and personal risk factors may influence this finding.",
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AU - Borghi, Alessandro

AU - Corazza, Monica

AU - Chiaranda, Giorgio

AU - Michiara, Maria

AU - Mangone, Lucia

AU - Caruso, Bianca

AU - Falcini, Fabio

AU - Maestri, Iva

AU - Ferretti, Stefano

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AB - Background: previous research on the risk of subsequent, primary non-cutaneous malignancies among patients with non-melanoma skin cancers (NMSCs) led to conflicting results. We aimed to investigate a possible link between NMSC and second primary malignancies by using the population-based data available in cancer registries. Methods: this observational study retrospectively assessed the risk of occurrence of both synchronous and methachronous second primary tumours in a cohort of cancer patients whose first diagnosis was NMSC. The cohort came from the network of general cancer registries of the Emilia-Romagna Region, northeast Italy, in the period between 1978 and 2012, and was compared with the general population living in the same area. Two main indexes were used: i) Standardized Incidence Ratio (SIR), calculated as the ratio between the observed and the expected number of second cancers and ii) Excess Absolute Risk (EAR), expressing the absolute excess or deficit of second cancer incidence. Results: in the period analysed (1978–2012, 72,503,157 person/years, PYs), 89,912 primary NMSC were found in 76,414 patients. Among them, 14,195 developed a second primary cancer in the subsequent 501,763 follow-up PYs. NMSC patients showed an overall SIR of 1.22 (CI 95% 1.20-1,24) and an EAR of 5.11 cases/1000 PYs (CI 95% 4.48–5.74). Conclusions: the study results showed that NMSC patients had an increase in relative risk and, at least for some tumours, in absolute risk of developing a second cancer when compared with the general population. Genetic, environmental and personal risk factors may influence this finding.

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