TY - JOUR
T1 - Secondary acute promyelocytic leukemia with t(8;21) and t(9;22) at onset and loss of the philadelphia chromosome at relapse
AU - Dallorso, Sandro
AU - Sessarego, Mario
AU - Garré, Maria Luisa
AU - Haupt, Riccardo
AU - Pasino, Mirella
AU - Sansone, Raffaele
PY - 1990/7/1
Y1 - 1990/7/1
N2 - The translocation (8;21) is a typical marker of the M2 subtype of acute nonlymphocytic leukemia, whereas the Philadelphia (Ph) chromosome is predominantly associated with chronic myelogenous leukemia, and seldom with immature acute leukemia, either lymphoblastic or nonlymphoblastic. Furthermore, the association between t(8;21) and a Ph in the same cell is extremely rare. We present a case of secondary acute promyelocytic leukemia with a karyotype 46,XY,t(8;21), t(9;22) at onset. At relapse the patient lost the Ph, while maintaining the t(8;21). This apparently paradoxical pattern of cytogenetic features and evolution is discussed.
AB - The translocation (8;21) is a typical marker of the M2 subtype of acute nonlymphocytic leukemia, whereas the Philadelphia (Ph) chromosome is predominantly associated with chronic myelogenous leukemia, and seldom with immature acute leukemia, either lymphoblastic or nonlymphoblastic. Furthermore, the association between t(8;21) and a Ph in the same cell is extremely rare. We present a case of secondary acute promyelocytic leukemia with a karyotype 46,XY,t(8;21), t(9;22) at onset. At relapse the patient lost the Ph, while maintaining the t(8;21). This apparently paradoxical pattern of cytogenetic features and evolution is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0025311870&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025311870&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(90)90260-H
DO - 10.1016/0165-4608(90)90260-H
M3 - Article
C2 - 2357686
AN - SCOPUS:0025311870
VL - 47
SP - 41
EP - 46
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -