Secondary breast angiosarcoma and paclitaxeldependent prolonged disease control

Report of two cases and review of the literature

Donatella Gambini, Roberto Visintin, Elisa Locatelli, Claudia Bareggi, Barbara Galassi, Letterio Runza, Concetta Blundo, Irina Sosnovskikh, Maurizio Tomirotti

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Secondary breast angiosarcomas are a well-known entity generally characterized by a poor outcome, especially in patients with advanced disease. Among the drugs with demonstrated activity, taxane derivatives are one of the most effective histology-driven treatments against angiosarcomas. We report two cases of secondary breast angiosarcoma, both characterized by a very peculiar behavior towards paclitaxel. Both patients showed local recurrence of angiosarcoma after primary surgery, and they achieved complete remission following treatment with weekly paclitaxel. When a locoregional recurrence was observed as a result of a brief treatment interruption or a treatment delay, a new complete remission was rapidly achieved with the resumption of the drug, without evidence of any significant adverse effects.

Original languageEnglish
Pages (from-to)e60-e63
JournalTumori
Volume101
Issue number2
DOIs
Publication statusPublished - Mar 1 2015

Fingerprint

Hemangiosarcoma
Paclitaxel
Recurrence
Therapeutics
Pharmaceutical Preparations
Histology
Angiosarcoma of the breast
taxane

Keywords

  • Angiogenesis
  • Paclitaxel
  • Secondary breast angiosarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Secondary breast angiosarcoma and paclitaxeldependent prolonged disease control : Report of two cases and review of the literature. / Gambini, Donatella; Visintin, Roberto; Locatelli, Elisa; Bareggi, Claudia; Galassi, Barbara; Runza, Letterio; Blundo, Concetta; Sosnovskikh, Irina; Tomirotti, Maurizio.

In: Tumori, Vol. 101, No. 2, 01.03.2015, p. e60-e63.

Research output: Contribution to journalArticle

Gambini, D, Visintin, R, Locatelli, E, Bareggi, C, Galassi, B, Runza, L, Blundo, C, Sosnovskikh, I & Tomirotti, M 2015, 'Secondary breast angiosarcoma and paclitaxeldependent prolonged disease control: Report of two cases and review of the literature', Tumori, vol. 101, no. 2, pp. e60-e63. https://doi.org/10.5301/tj.5000252
Gambini, Donatella ; Visintin, Roberto ; Locatelli, Elisa ; Bareggi, Claudia ; Galassi, Barbara ; Runza, Letterio ; Blundo, Concetta ; Sosnovskikh, Irina ; Tomirotti, Maurizio. / Secondary breast angiosarcoma and paclitaxeldependent prolonged disease control : Report of two cases and review of the literature. In: Tumori. 2015 ; Vol. 101, No. 2. pp. e60-e63.
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