Secondary breast angiosarcoma and paclitaxeldependent prolonged disease control: Report of two cases and review of the literature

Donatella Gambini, Roberto Visintin, Elisa Locatelli, Claudia Bareggi, Barbara Galassi, Letterio Runza, Concetta Blundo, Irina Sosnovskikh, Maurizio Tomirotti

Research output: Contribution to journalArticle

Abstract

Secondary breast angiosarcomas are a well-known entity generally characterized by a poor outcome, especially in patients with advanced disease. Among the drugs with demonstrated activity, taxane derivatives are one of the most effective histology-driven treatments against angiosarcomas. We report two cases of secondary breast angiosarcoma, both characterized by a very peculiar behavior towards paclitaxel. Both patients showed local recurrence of angiosarcoma after primary surgery, and they achieved complete remission following treatment with weekly paclitaxel. When a locoregional recurrence was observed as a result of a brief treatment interruption or a treatment delay, a new complete remission was rapidly achieved with the resumption of the drug, without evidence of any significant adverse effects.

Original languageEnglish
Pages (from-to)e60-e63
JournalTumori
Volume101
Issue number2
DOIs
Publication statusPublished - Mar 1 2015

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Hemangiosarcoma
Paclitaxel
Recurrence
Therapeutics
Pharmaceutical Preparations
Histology
Angiosarcoma of the breast
taxane

Keywords

  • Angiogenesis
  • Paclitaxel
  • Secondary breast angiosarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Secondary breast angiosarcoma and paclitaxeldependent prolonged disease control : Report of two cases and review of the literature. / Gambini, Donatella; Visintin, Roberto; Locatelli, Elisa; Bareggi, Claudia; Galassi, Barbara; Runza, Letterio; Blundo, Concetta; Sosnovskikh, Irina; Tomirotti, Maurizio.

In: Tumori, Vol. 101, No. 2, 01.03.2015, p. e60-e63.

Research output: Contribution to journalArticle

Gambini, D, Visintin, R, Locatelli, E, Bareggi, C, Galassi, B, Runza, L, Blundo, C, Sosnovskikh, I & Tomirotti, M 2015, 'Secondary breast angiosarcoma and paclitaxeldependent prolonged disease control: Report of two cases and review of the literature', Tumori, vol. 101, no. 2, pp. e60-e63. https://doi.org/10.5301/tj.5000252
Gambini, Donatella ; Visintin, Roberto ; Locatelli, Elisa ; Bareggi, Claudia ; Galassi, Barbara ; Runza, Letterio ; Blundo, Concetta ; Sosnovskikh, Irina ; Tomirotti, Maurizio. / Secondary breast angiosarcoma and paclitaxeldependent prolonged disease control : Report of two cases and review of the literature. In: Tumori. 2015 ; Vol. 101, No. 2. pp. e60-e63.
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