Secondary cytoreduction plus oxaliplatin-based HIPEC in platinum-sensitive recurrent ovarian cancer patients: A pilot study

A. Fagotti, I. Paris, F. Grimolizzi, F. Fanfani, G. Vizzielli, A. Naldini, G. Scambia

Research output: Contribution to journalArticle

Abstract

Objectives: To assess feasibility, complications and efficacy of secondary surgical cytoreduction (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in a selected group of platinum-sensitive recurrent ovarian cancer patients. Methods: Recurrent ovarian cancer patients with a platinum-free interval of at least 6 months were prospectively enrolled. After complete CRS they were submitted to intraperitoneal perfusion of oxaplatinum (460 mg/m 2) heated to 41.5 °C for 30 min. Then they received systemic chemotherapy with taxotere 75 mg/m 2 and oxaliplatin 100 mg/m 2 for 6 cycles. Patients were followed up routinely until recurrence or death. Results: Twenty-five recurrent ovarian cancer patients were valuable for the study. The median Platinum Free Interval (PFI) was 25 months (range 7-67). The majority of the patients (76%) had diffuse carcinosis. Nobody had ascites. An optimal residual disease was obtained in all patients. The median duration of CRS + HIPEC was 312 min (range138-619). Median intensive care unit (ICU) stay was 2 days (1-6), median hospital stay was 13 days (7-30). Post-operative major complications were observed in 7 patients (28%). Post-operative mortality was 0%. With a median follow-up time of 18 months (range 3-38), 24 patients (96%) are alive, but seven women (28%) have relapsed. Conclusions: Adequate pre-operative selection can improve feasibility of CRS and HIPEC. Morbidity rate is comparable to aggressive cytoreduction without HIPEC. Although associated with some post-operative morbidity, long-term results are encouraging, waiting for larger series and longer follow-up data.

Original languageEnglish
Pages (from-to)335-340
Number of pages6
JournalGynecologic Oncology
Volume113
Issue number3
DOIs
Publication statusPublished - Jun 2009

Keywords

  • HIPEC
  • Ovarian cancer
  • Oxaliplatin
  • Recurrence
  • Secondary cytoreduction

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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    Fagotti, A., Paris, I., Grimolizzi, F., Fanfani, F., Vizzielli, G., Naldini, A., & Scambia, G. (2009). Secondary cytoreduction plus oxaliplatin-based HIPEC in platinum-sensitive recurrent ovarian cancer patients: A pilot study. Gynecologic Oncology, 113(3), 335-340. https://doi.org/10.1016/j.ygyno.2009.03.004