Secondary cytotoxic response in vitro against Moloney lymphoma cells antigenically altered by drug treatment in vivo

A. Santoni, Y. Kinney, A. Goldin

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12 Citations (Scopus)

Abstract

Cell-mediated cytotoxic response in vitro to a Moloney strain of murine leukemia virus-induced tumor (LSTRA) altered by 5-(3,3-dimethyl-1- triazeno)imidazole-4-carboxamide (DTIC) was investigated with the use of mixed-leukocyte tumor cell cultures (MLTC). As assessed by means of a short-term 51Cr-release assay, minimal or no cytolytic activity was generated in primary MLTC. In contrast, high specific cytotoxic response against the altered tumor was obtained in secondary MLTC. Partial cross-reactivity was found between the LSTRA and LSTRA/DTIC tumor lines.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalJournal of the National Cancer Institute
Volume60
Issue number1
Publication statusPublished - 1978

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Lymphoma
Pharmaceutical Preparations
Neoplasms
Leukocytes
Cell Culture Techniques
Moloney murine leukemia virus
Dacarbazine
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Secondary cytotoxic response in vitro against Moloney lymphoma cells antigenically altered by drug treatment in vivo. / Santoni, A.; Kinney, Y.; Goldin, A.

In: Journal of the National Cancer Institute, Vol. 60, No. 1, 1978, p. 109-112.

Research output: Contribution to journalArticle

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