Secondary ''incidental'' REM sleep behavior disorder: Do we ever think of it?

Raffaele Manni, Pietro Luca Ratti, Michele Terzaghi

Research output: Contribution to journalArticlepeer-review


Most secondary forms of REM sleep behavior disorder are associated with neurodegenerative diseases belonging to the α-synucleinopathies or with narcolepsy. However, RBD may also occur in subacute- or acute-onset conditions involving the central nervous system, irrespective of subjects' age and sex, and with or without relapse at follow-up. These conditions include structural brain lesions (vascular, demyelinating, tumoral, iatrogenic, etc.), CNS diseases (encephalitis, Guillain-Barré syndrome, etc.), forms induced by drug consumption or alcohol withdrawal, and possibly post-traumatic stress disorder. This review focuses on these forms of RBD, which are referred to as '. acute' as they occur as incidental phenomena within the context of other subacute- or acute-onset disorders. In these cases, RBD does not appear as a 'classical' clinical feature of the underlying condition, but rather as an intercurrent, somewhat unexpected phenomenon that deserves consideration in routine clinical practice, in order to avoid misdiagnoses and mistreatments.

Original languageEnglish
JournalSleep Medicine
Issue numberSUPPL. 2
Publication statusPublished - Dec 2011


  • Acute neurological disorders
  • Acute RBD
  • Acute sleep-related paroxysmal episodes
  • CNS disorders
  • REM sleep behavior disorder
  • Secondary RBD

ASJC Scopus subject areas

  • Medicine(all)


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