Secondary leiomyosarcomas: A report of 4 cases

Gianni Bisogno, Monica Spiller, Giovanni Scarzello, Giovanni Cecchetto, Maurizio Mascarin, Paolo Indolfi, A. Ferrari, Modesto Carli

Research output: Contribution to journalArticlepeer-review


Survivors of childhood cancer risk developing second malignant neoplasms (SMN). A small proportion of SMNs is represented by soft tissue sarcoma (STS), including leiomyosarcoma. The files of the STS Italian Cooperative Group (ICG) were reviewed and 4 patients with secondary leiomyosarcoma were, identified, only two of them still alive. In 3 cases, the leiomyosarcoma occurred in the radiation field. The authors found no clear differences between primary and secondary leiomyosarcomas, but leiomyosarcoma proved to be the most frequent SMN registered by the ICG, confirming the need for further studies to identify any distinctive features or syndromes.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalPediatric Hematology and Oncology
Issue number2
Publication statusPublished - Mar 2005


  • Leiomyosarcoma
  • Second malignancy
  • Soft tissue sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health


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