Secondary parkinsonism due to focal substantia nigra lesions: A PET study with [18F]FDG and [18F]fluorodopa

H. Boecker, A. Weindl, K. Leenders, A. Antonini, T. Kuwert, F. Kruggel, H. Gräfin V. Einsiedel, B. Conrad

Research output: Contribution to journalArticle

Abstract

We present a 71 year old woman with predominantly right sided parkinsonism of sudden onset, but without tremor. Magnetic resonance imaging (MRI) depicted lesions affecting the substantia nigra (SN) bilaterally, but more pronounced on the left side. There were no other discernible structural lesions. Using positron emission tomography (PET), we investigated regional cerebral metabolic rate of glucose (rCMRG) using the tracer [18F]-fluorodeoxyglucose (FDG), and striatal dopa decarboxylase capacity using the tracer [18F]-L-6-fluorodopa (FDOPA). The degree and pattern of distribution of FDOPA uptake reductions (putamen > caudate nuclei) were similar to those in idiopathic Parkinson's disease (PD). FDG uptake also revealed similar changes (reductions in frontal cortex and cerebellum, but increases in thalamus), except for putamen which showed reduced rCMRG. In conclusion, the absence of tremor at rest accords with experimental SN lesions. The PET findings in this atypical condition are explained in terms of deafferentation of various brain regions involved in motor control. Furthermore, they illustrate the metabolic effects related to acute focal lesions of the SN as opposed to the progressive degeneration in idiopathic PD and may serve to help unravel the complicated pathophysiology underlying these conditions.

Original languageEnglish
Pages (from-to)387-392
Number of pages6
JournalActa Neurologica Scandinavica
Volume93
Issue number6
Publication statusPublished - 1996

Fingerprint

Secondary Parkinson Disease
Fluorodeoxyglucose F18
Substantia Nigra
Positron-Emission Tomography
Putamen
Tremor
Parkinson Disease
Dopa Decarboxylase
Corpus Striatum
Glucose
Caudate Nucleus
Parkinsonian Disorders
Frontal Lobe
Thalamus
Cerebellum
Magnetic Resonance Imaging
Brain
fluorodopa F 18

Keywords

  • [F]fluorodopa
  • PET
  • Position emission tomography
  • Secondary parkinsonism
  • Substantia nigra
  • Vascular parkinsonism

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Boecker, H., Weindl, A., Leenders, K., Antonini, A., Kuwert, T., Kruggel, F., ... Conrad, B. (1996). Secondary parkinsonism due to focal substantia nigra lesions: A PET study with [18F]FDG and [18F]fluorodopa. Acta Neurologica Scandinavica, 93(6), 387-392.

Secondary parkinsonism due to focal substantia nigra lesions : A PET study with [18F]FDG and [18F]fluorodopa. / Boecker, H.; Weindl, A.; Leenders, K.; Antonini, A.; Kuwert, T.; Kruggel, F.; Gräfin V. Einsiedel, H.; Conrad, B.

In: Acta Neurologica Scandinavica, Vol. 93, No. 6, 1996, p. 387-392.

Research output: Contribution to journalArticle

Boecker, H, Weindl, A, Leenders, K, Antonini, A, Kuwert, T, Kruggel, F, Gräfin V. Einsiedel, H & Conrad, B 1996, 'Secondary parkinsonism due to focal substantia nigra lesions: A PET study with [18F]FDG and [18F]fluorodopa', Acta Neurologica Scandinavica, vol. 93, no. 6, pp. 387-392.
Boecker H, Weindl A, Leenders K, Antonini A, Kuwert T, Kruggel F et al. Secondary parkinsonism due to focal substantia nigra lesions: A PET study with [18F]FDG and [18F]fluorodopa. Acta Neurologica Scandinavica. 1996;93(6):387-392.
Boecker, H. ; Weindl, A. ; Leenders, K. ; Antonini, A. ; Kuwert, T. ; Kruggel, F. ; Gräfin V. Einsiedel, H. ; Conrad, B. / Secondary parkinsonism due to focal substantia nigra lesions : A PET study with [18F]FDG and [18F]fluorodopa. In: Acta Neurologica Scandinavica. 1996 ; Vol. 93, No. 6. pp. 387-392.
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