Secondary stroke prevention in women

Monica Acciarresi, Paola De Rango, Francesca Romana Pezzella, Paola Santalucia, Serena Amici, Maurizio Paciaroni, Valeria Mommi, Giancarlo Agnelli, Valeria Caso

Research output: Contribution to journalArticlepeer-review


In a meta-analysis of results from 21 randomized trials comparing antiplatelet therapy with placebo in 18,270 patients with prior stroke or transient ischemic attack, antiplatelet therapy was associated with a 28% relative odds reduction in nonfatal strokes and a 16% reduction in fatal strokes, while another trial for secondary prevention with atorvastastin 80 mg showed a 16% risk reduction in time to first occurrence of stroke (adjusted hazard ratio: 0.84, 95% CI: 0.71-0.99). However, few studies have examined the sex differences regarding the efficacy of these treatments. Specifically, recent studies have reported higher rates of perioperative complications during endarterectomy in women. Nonetheless, to date, the data on the effects of carotid artery stenting in women, coming from diverse studies and meta-analyses, have been limited owing to the small number of female patients examined. Owing to this, the evidence of the benefit for women is unclear. Peculiar pathophysiological aspects of stroke, the higher stroke risk in some specific periods in life (e.g., pregnancy, puerperium and older age) and worse documented stroke outcome in women suggest that sex does matter in stroke management. Thus, future randomized controlled trials need to be sex-balanced, in order to better understand the efficacy of appropriate secondary stroke prevention therapy in women.

Original languageEnglish
Pages (from-to)391-397
Number of pages7
JournalWomen's Health
Issue number3
Publication statusPublished - May 2011


  • antiplatelets
  • carotid stenosis
  • secondary prevention
  • stroke
  • women

ASJC Scopus subject areas

  • Medicine(all)


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