Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair

Maria Mirotsou, Zhongyan Zhang, Arjun Deb, Lunan Zhang, Massimiliano Gnecchi, Nicolas Noiseux, Hui Mu, Alok Pachori, Victor Dzau

Research output: Contribution to journalArticle

367 Citations (Scopus)

Abstract

Stem cell therapy has emerged as a promising tool for the treatment of a variety of diseases. Previously, we have shown that Akt-modified mesenchymal stem cells mediate tissue repair through paracrine mechanisms. Using a comprehensive functional genomic strategy, we show that secreted frizzled related protein 2 (Sfrp2) is the key stem cell paracrine factor that mediates myocardial survival and repair after ischemic injury. Sfrp2 is known to modulate Wnt signaling, and we demonstrate that cardiomyocytes treated with secreted frizzled related protein increase cellular β-catenin and up-regulate expression of antiapoptotic genes. These findings reveal the key role played by Sfrp2 in mediating the paracrine effects of Akt-mesenchymal stem cells on tissue repair and identify modulation of Wnt signaling as a therapeutic target for heart disease.

Original languageEnglish
Pages (from-to)1643-1648
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number5
DOIs
Publication statusPublished - Jan 30 2007

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Mesenchymal Stromal Cells
Catenins
Stem Cell Factor
Cell- and Tissue-Based Therapy
Cardiac Myocytes
Heart Diseases
Up-Regulation
Stem Cells
Gene Expression
FRZB protein
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. / Mirotsou, Maria; Zhang, Zhongyan; Deb, Arjun; Zhang, Lunan; Gnecchi, Massimiliano; Noiseux, Nicolas; Mu, Hui; Pachori, Alok; Dzau, Victor.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 5, 30.01.2007, p. 1643-1648.

Research output: Contribution to journalArticle

Mirotsou, Maria ; Zhang, Zhongyan ; Deb, Arjun ; Zhang, Lunan ; Gnecchi, Massimiliano ; Noiseux, Nicolas ; Mu, Hui ; Pachori, Alok ; Dzau, Victor. / Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. In: Proceedings of the National Academy of Sciences of the United States of America. 2007 ; Vol. 104, No. 5. pp. 1643-1648.
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