Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair

Maria Mirotsou; Zhongyan Zhang; Arjun Deb; Lunan Zhang; Massimiliano Gnecchi; Nicolas Noiseux; Hui Mu; Alok Pachori; Victor Dzau

doi:10.1073/pnas.0610024104

Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair

Maria Mirotsou, Zhongyan Zhang, Arjun Deb, Lunan Zhang, Massimiliano Gnecchi, Nicolas Noiseux, Hui Mu, Alok Pachori, Victor Dzau

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Stem cell therapy has emerged as a promising tool for the treatment of a variety of diseases. Previously, we have shown that Akt-modified mesenchymal stem cells mediate tissue repair through paracrine mechanisms. Using a comprehensive functional genomic strategy, we show that secreted frizzled related protein 2 (Sfrp2) is the key stem cell paracrine factor that mediates myocardial survival and repair after ischemic injury. Sfrp2 is known to modulate Wnt signaling, and we demonstrate that cardiomyocytes treated with secreted frizzled related protein increase cellular β-catenin and up-regulate expression of antiapoptotic genes. These findings reveal the key role played by Sfrp2 in mediating the paracrine effects of Akt-mesenchymal stem cells on tissue repair and identify modulation of Wnt signaling as a therapeutic target for heart disease.

Original language	English
Pages (from-to)	1643-1648
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	104
Issue number	5
DOIs	https://doi.org/10.1073/pnas.0610024104
Publication status	Published - Jan 30 2007

ASJC Scopus subject areas

Genetics
General

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Mirotsou, M., Zhang, Z., Deb, A., Zhang, L., Gnecchi, M., Noiseux, N., Mu, H., Pachori, A., & Dzau, V. (2007). Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proceedings of the National Academy of Sciences of the United States of America, 104(5), 1643-1648. https://doi.org/10.1073/pnas.0610024104

Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. / Mirotsou, Maria; Zhang, Zhongyan; Deb, Arjun; Zhang, Lunan; Gnecchi, Massimiliano; Noiseux, Nicolas; Mu, Hui; Pachori, Alok; Dzau, Victor.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 5, 30.01.2007, p. 1643-1648.

Research output: Contribution to journal › Article › peer-review

Mirotsou, M, Zhang, Z, Deb, A, Zhang, L, Gnecchi, M, Noiseux, N, Mu, H, Pachori, A & Dzau, V 2007, 'Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair', Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 5, pp. 1643-1648. https://doi.org/10.1073/pnas.0610024104

Mirotsou, Maria ; Zhang, Zhongyan ; Deb, Arjun ; Zhang, Lunan ; Gnecchi, Massimiliano ; Noiseux, Nicolas ; Mu, Hui ; Pachori, Alok ; Dzau, Victor. / Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. In: Proceedings of the National Academy of Sciences of the United States of America. 2007 ; Vol. 104, No. 5. pp. 1643-1648.

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