Secretory IgA system and colon-rectum carcinoma. Immunohistochemical study

G. G. Giordano, A. M. Bevilacqua, M. V. Carriero

Research output: Contribution to journalArticlepeer-review


The main components of the secretory IgA system are IgA and J chain, synthesized by local plasmacells, and secretory component (SC) which is a product of epithelial glandular cells. This system plays an important role in immunologic defense mechanisms against antigens of various type in the colon-rectum mucosa. The present study reports the results of the identification of IgA and SC by immunoperoxidase method in colon-rectum carcinoma. The results mainly show: a) occurrence of IgA and SC positivities in 86% and 80%, respectively, or carcinoma cases; b) a correlation between differentiation degree of carcinoma and immunohistochemical findings.

Original languageEnglish
Pages (from-to)383-388
Number of pages6
JournalJournal of Experimental and Clinical Cancer Research
Issue number4
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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