Segmental resection of distal ureter with termino-terminal ureteric anastomosis vs bladder cuff removal and ureteric re-implantation for upper tract urothelial carcinoma

results of a multicentre study

Alberto Abrate, Francesco Sessa, Arcangelo Sebastianelli, Mirko Preto, Alberto Olivero, Virginia Varca, Andrea Benelli, Riccardo Campi, Maurizio Sessa, Carlo Pavone, Vincenzo Serretta, Marco Vella, Eugenio Brunocilla, Sergio Serni, Carlo Trombetta, Carlo Terrone, Andrea Gregori, Andrea Lissiani, Paolo Gontero, Riccardo Schiavina & 2 others Mauro Gacci, Alchiede Simonato

Research output: Contribution to journalArticle

Abstract

Objectives: To compare overall (OS), cancer-specific (CSS), recurrence-free survival (RFS) and postoperative renal function amongst patients with upper tract urothelial carcinoma (UTUC) of the distal (lower lumbar and pelvic) ureter, electively treated with segmental resection and termino-terminal anastomosis (TT) vs bladder cuff removal and ureteric re-implantation (RR). Patients and methods: A multicentre retrospective study, including 84 patients diagnosed with UTUC of the distal ureter and treated with TT or RR, is presented. The primary endpoint was to compare TT and RR in terms of OS, CSS and RFS. As a secondary outcome, we compared the postoperative creatinine values as an index of renal function in the two groups. Results: Of 521 patients with UTUC, 65 (77.4%) and 19 (22.6%) patients underwent RR and TT, respectively. Pre- and postoperative characteristics were not statistically different between the two groups. The median follow-up period was 22.7 months. Patients treated with TT and those treated with RR did not have significantly different 5-year OS, CSS or RFS (73.7% vs 92.3%, P = 0.052; 94.7% vs 95.4%, P = 0.970: and 63.2% vs 53.9%, P = 0.489, respectively). No difference in postoperative creatinine variation emerged in association with the surgical technique (P = 0.411). Conclusion: Patients treated with TT or RR for UTUC showed comparable OS, CSS, RFS and postoperative renal function. Our data suggest that bladder cuff removal is not imperative in the treatment of distal ureteric UTUC, and TT can be a safe solution in selected cases.

Original languageEnglish
JournalBJU International
DOIs
Publication statusPublished - Jan 1 2019

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Ureter
Multicenter Studies
Urinary Bladder
Carcinoma
Recurrence
Survival
Kidney
Creatinine
Retrospective Studies
Neoplasms

Keywords

  • #utuc
  • renal function
  • segmental ureterectomy
  • survival
  • termino-terminal ureteroureterostomy
  • upper tract urothelial carcinoma
  • ureteric re-implantation

ASJC Scopus subject areas

  • Urology

Cite this

Segmental resection of distal ureter with termino-terminal ureteric anastomosis vs bladder cuff removal and ureteric re-implantation for upper tract urothelial carcinoma : results of a multicentre study. / Abrate, Alberto; Sessa, Francesco; Sebastianelli, Arcangelo; Preto, Mirko; Olivero, Alberto; Varca, Virginia; Benelli, Andrea; Campi, Riccardo; Sessa, Maurizio; Pavone, Carlo; Serretta, Vincenzo; Vella, Marco; Brunocilla, Eugenio; Serni, Sergio; Trombetta, Carlo; Terrone, Carlo; Gregori, Andrea; Lissiani, Andrea; Gontero, Paolo; Schiavina, Riccardo; Gacci, Mauro; Simonato, Alchiede.

In: BJU International, 01.01.2019.

Research output: Contribution to journalArticle

Abrate, A, Sessa, F, Sebastianelli, A, Preto, M, Olivero, A, Varca, V, Benelli, A, Campi, R, Sessa, M, Pavone, C, Serretta, V, Vella, M, Brunocilla, E, Serni, S, Trombetta, C, Terrone, C, Gregori, A, Lissiani, A, Gontero, P, Schiavina, R, Gacci, M & Simonato, A 2019, 'Segmental resection of distal ureter with termino-terminal ureteric anastomosis vs bladder cuff removal and ureteric re-implantation for upper tract urothelial carcinoma: results of a multicentre study', BJU International. https://doi.org/10.1111/bju.14697
Abrate, Alberto ; Sessa, Francesco ; Sebastianelli, Arcangelo ; Preto, Mirko ; Olivero, Alberto ; Varca, Virginia ; Benelli, Andrea ; Campi, Riccardo ; Sessa, Maurizio ; Pavone, Carlo ; Serretta, Vincenzo ; Vella, Marco ; Brunocilla, Eugenio ; Serni, Sergio ; Trombetta, Carlo ; Terrone, Carlo ; Gregori, Andrea ; Lissiani, Andrea ; Gontero, Paolo ; Schiavina, Riccardo ; Gacci, Mauro ; Simonato, Alchiede. / Segmental resection of distal ureter with termino-terminal ureteric anastomosis vs bladder cuff removal and ureteric re-implantation for upper tract urothelial carcinoma : results of a multicentre study. In: BJU International. 2019.
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title = "Segmental resection of distal ureter with termino-terminal ureteric anastomosis vs bladder cuff removal and ureteric re-implantation for upper tract urothelial carcinoma: results of a multicentre study",
abstract = "Objectives: To compare overall (OS), cancer-specific (CSS), recurrence-free survival (RFS) and postoperative renal function amongst patients with upper tract urothelial carcinoma (UTUC) of the distal (lower lumbar and pelvic) ureter, electively treated with segmental resection and termino-terminal anastomosis (TT) vs bladder cuff removal and ureteric re-implantation (RR). Patients and methods: A multicentre retrospective study, including 84 patients diagnosed with UTUC of the distal ureter and treated with TT or RR, is presented. The primary endpoint was to compare TT and RR in terms of OS, CSS and RFS. As a secondary outcome, we compared the postoperative creatinine values as an index of renal function in the two groups. Results: Of 521 patients with UTUC, 65 (77.4{\%}) and 19 (22.6{\%}) patients underwent RR and TT, respectively. Pre- and postoperative characteristics were not statistically different between the two groups. The median follow-up period was 22.7 months. Patients treated with TT and those treated with RR did not have significantly different 5-year OS, CSS or RFS (73.7{\%} vs 92.3{\%}, P = 0.052; 94.7{\%} vs 95.4{\%}, P = 0.970: and 63.2{\%} vs 53.9{\%}, P = 0.489, respectively). No difference in postoperative creatinine variation emerged in association with the surgical technique (P = 0.411). Conclusion: Patients treated with TT or RR for UTUC showed comparable OS, CSS, RFS and postoperative renal function. Our data suggest that bladder cuff removal is not imperative in the treatment of distal ureteric UTUC, and TT can be a safe solution in selected cases.",
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T1 - Segmental resection of distal ureter with termino-terminal ureteric anastomosis vs bladder cuff removal and ureteric re-implantation for upper tract urothelial carcinoma

T2 - results of a multicentre study

AU - Abrate, Alberto

AU - Sessa, Francesco

AU - Sebastianelli, Arcangelo

AU - Preto, Mirko

AU - Olivero, Alberto

AU - Varca, Virginia

AU - Benelli, Andrea

AU - Campi, Riccardo

AU - Sessa, Maurizio

AU - Pavone, Carlo

AU - Serretta, Vincenzo

AU - Vella, Marco

AU - Brunocilla, Eugenio

AU - Serni, Sergio

AU - Trombetta, Carlo

AU - Terrone, Carlo

AU - Gregori, Andrea

AU - Lissiani, Andrea

AU - Gontero, Paolo

AU - Schiavina, Riccardo

AU - Gacci, Mauro

AU - Simonato, Alchiede

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives: To compare overall (OS), cancer-specific (CSS), recurrence-free survival (RFS) and postoperative renal function amongst patients with upper tract urothelial carcinoma (UTUC) of the distal (lower lumbar and pelvic) ureter, electively treated with segmental resection and termino-terminal anastomosis (TT) vs bladder cuff removal and ureteric re-implantation (RR). Patients and methods: A multicentre retrospective study, including 84 patients diagnosed with UTUC of the distal ureter and treated with TT or RR, is presented. The primary endpoint was to compare TT and RR in terms of OS, CSS and RFS. As a secondary outcome, we compared the postoperative creatinine values as an index of renal function in the two groups. Results: Of 521 patients with UTUC, 65 (77.4%) and 19 (22.6%) patients underwent RR and TT, respectively. Pre- and postoperative characteristics were not statistically different between the two groups. The median follow-up period was 22.7 months. Patients treated with TT and those treated with RR did not have significantly different 5-year OS, CSS or RFS (73.7% vs 92.3%, P = 0.052; 94.7% vs 95.4%, P = 0.970: and 63.2% vs 53.9%, P = 0.489, respectively). No difference in postoperative creatinine variation emerged in association with the surgical technique (P = 0.411). Conclusion: Patients treated with TT or RR for UTUC showed comparable OS, CSS, RFS and postoperative renal function. Our data suggest that bladder cuff removal is not imperative in the treatment of distal ureteric UTUC, and TT can be a safe solution in selected cases.

AB - Objectives: To compare overall (OS), cancer-specific (CSS), recurrence-free survival (RFS) and postoperative renal function amongst patients with upper tract urothelial carcinoma (UTUC) of the distal (lower lumbar and pelvic) ureter, electively treated with segmental resection and termino-terminal anastomosis (TT) vs bladder cuff removal and ureteric re-implantation (RR). Patients and methods: A multicentre retrospective study, including 84 patients diagnosed with UTUC of the distal ureter and treated with TT or RR, is presented. The primary endpoint was to compare TT and RR in terms of OS, CSS and RFS. As a secondary outcome, we compared the postoperative creatinine values as an index of renal function in the two groups. Results: Of 521 patients with UTUC, 65 (77.4%) and 19 (22.6%) patients underwent RR and TT, respectively. Pre- and postoperative characteristics were not statistically different between the two groups. The median follow-up period was 22.7 months. Patients treated with TT and those treated with RR did not have significantly different 5-year OS, CSS or RFS (73.7% vs 92.3%, P = 0.052; 94.7% vs 95.4%, P = 0.970: and 63.2% vs 53.9%, P = 0.489, respectively). No difference in postoperative creatinine variation emerged in association with the surgical technique (P = 0.411). Conclusion: Patients treated with TT or RR for UTUC showed comparable OS, CSS, RFS and postoperative renal function. Our data suggest that bladder cuff removal is not imperative in the treatment of distal ureteric UTUC, and TT can be a safe solution in selected cases.

KW - #utuc

KW - renal function

KW - segmental ureterectomy

KW - survival

KW - termino-terminal ureteroureterostomy

KW - upper tract urothelial carcinoma

KW - ureteric re-implantation

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