Segmental transcatheter arterial chemoembolization treatment in patients with cirrhosis and inoperable hepatocellular carcinomas

Silvia Saccheri, Andrea Lovaria, Angelo Sangiovanni, Antonio Nicolini, Cristina De Fazio, Guido Ronchi, Pierangelo Fasani, Ersilio Del Ninno, Massimo Colombo

Research output: Contribution to journalArticle

Abstract

PURPOSE: To establish whether segmental transcatheter arterial chemoembolization (TACE) treatment may improve the rates of survival in patients with compensated cirrhosis and inoperable hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Fifty-six patients with compensated cirrhosis and inoperable HCC were treated with segmental TACE. One hundred forty treatments (mean, 2.5 per patient; 30-60 mg Epirubicin, 4-10 mL Lipiodol, and Gelfoam particles) were administered. RESULTS: During the 69-month study, 25 patients (45%) died of tumor progression, 12 (21%) of liver failure, nine (16%) of gastrointestinal hemorrhage, and three (5%) of other causes; seven patients (13%) are still alive. The 3-year rate of survival was 32%. Intention-to-treat analysis determined that patients with Child-Pugh class A disease (n = 44; 79%) or a single

Original languageEnglish
Pages (from-to)995-999
Number of pages5
JournalJournal of Vascular and Interventional Radiology
Volume13
Issue number10
Publication statusPublished - Oct 1 2002

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Keywords

  • Chemoembolization
  • Liver neoplasms, chemotherapeutic infusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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