Segmental transcatheter arterial chemoembolization treatment in patients with cirrhosis and inoperable hepatocellular carcinomas

Silvia Saccheri, Andrea Lovaria, Angelo Sangiovanni, Antonio Nicolini, Cristina De Fazio, Guido Ronchi, Pierangelo Fasani, Ersilio Del Ninno, Massimo Colombo

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

PURPOSE: To establish whether segmental transcatheter arterial chemoembolization (TACE) treatment may improve the rates of survival in patients with compensated cirrhosis and inoperable hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Fifty-six patients with compensated cirrhosis and inoperable HCC were treated with segmental TACE. One hundred forty treatments (mean, 2.5 per patient; 30-60 mg Epirubicin, 4-10 mL Lipiodol, and Gelfoam particles) were administered. RESULTS: During the 69-month study, 25 patients (45%) died of tumor progression, 12 (21%) of liver failure, nine (16%) of gastrointestinal hemorrhage, and three (5%) of other causes; seven patients (13%) are still alive. The 3-year rate of survival was 32%. Intention-to-treat analysis determined that patients with Child-Pugh class A disease (n = 44; 79%) or a single

Original languageEnglish
Pages (from-to)995-999
Number of pages5
JournalJournal of Vascular and Interventional Radiology
Volume13
Issue number10
Publication statusPublished - Oct 1 2002

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Hepatocellular Carcinoma
Fibrosis
Therapeutics
Survival Rate
Absorbable Gelatin Sponge
Ethiodized Oil
Epirubicin
Intention to Treat Analysis
Gastrointestinal Hemorrhage
Liver Failure
Neoplasms

Keywords

  • Chemoembolization
  • Liver neoplasms, chemotherapeutic infusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Segmental transcatheter arterial chemoembolization treatment in patients with cirrhosis and inoperable hepatocellular carcinomas. / Saccheri, Silvia; Lovaria, Andrea; Sangiovanni, Angelo; Nicolini, Antonio; De Fazio, Cristina; Ronchi, Guido; Fasani, Pierangelo; Del Ninno, Ersilio; Colombo, Massimo.

In: Journal of Vascular and Interventional Radiology, Vol. 13, No. 10, 01.10.2002, p. 995-999.

Research output: Contribution to journalArticle

Saccheri, Silvia ; Lovaria, Andrea ; Sangiovanni, Angelo ; Nicolini, Antonio ; De Fazio, Cristina ; Ronchi, Guido ; Fasani, Pierangelo ; Del Ninno, Ersilio ; Colombo, Massimo. / Segmental transcatheter arterial chemoembolization treatment in patients with cirrhosis and inoperable hepatocellular carcinomas. In: Journal of Vascular and Interventional Radiology. 2002 ; Vol. 13, No. 10. pp. 995-999.
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AU - Lovaria, Andrea

AU - Sangiovanni, Angelo

AU - Nicolini, Antonio

AU - De Fazio, Cristina

AU - Ronchi, Guido

AU - Fasani, Pierangelo

AU - Del Ninno, Ersilio

AU - Colombo, Massimo

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