Segregation of virulent influenza A(H1N1) variants in the lower respiratory tract of critically ill patients during the 2010-2011 seasonal epidemic

Antonio Piralla, Elena Pariani, Francesca Rovida, Giulia Campanini, Alba Muzzi, Vincenzo Emmi, Giorgio A. Iotti, Antonio Pesenti, Pier Giulio Conaldi, Alessandro Zanetti, Fausto Baldanti

Research output: Contribution to journalArticle

Abstract

Background: Since its appearance in 2009, the pandemic influenza A(H1N1) virus circulated worldwide causing several severe infections. Methods: Respiratory samples from patients with 2009 influenza A(H1N1) and acute respiratory distress attending 24 intensive care units (ICUs) as well as from patients with lower respiratory tract infections not requiring ICU admission and community upper respiratory tract infections in the Lombardy region (10 million inhabitants) of Italy during the 2010-2011 winter-spring season, were analyzed. Results: In patients with severe ILI, the viral load was higher in bronchoalveolar lavage (BAL) with respect to nasal swab (NS), (p

Original languageEnglish
Article numbere28332
JournalPLoS One
Volume6
Issue number12
DOIs
Publication statusPublished - Dec 14 2011

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Intensive care units
respiratory system
Critical Illness
influenza
Respiratory System
Human Influenza
Respiratory Tract Infections
respiratory tract diseases
Intensive Care Units
Italy
Viruses
H1N1 Subtype Influenza A Virus
Influenza A virus
Bronchoalveolar Lavage
Pandemics
pandemic
distress
viral load
Viral Load
Nose

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

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abstract = "Background: Since its appearance in 2009, the pandemic influenza A(H1N1) virus circulated worldwide causing several severe infections. Methods: Respiratory samples from patients with 2009 influenza A(H1N1) and acute respiratory distress attending 24 intensive care units (ICUs) as well as from patients with lower respiratory tract infections not requiring ICU admission and community upper respiratory tract infections in the Lombardy region (10 million inhabitants) of Italy during the 2010-2011 winter-spring season, were analyzed. Results: In patients with severe ILI, the viral load was higher in bronchoalveolar lavage (BAL) with respect to nasal swab (NS), (p",
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T1 - Segregation of virulent influenza A(H1N1) variants in the lower respiratory tract of critically ill patients during the 2010-2011 seasonal epidemic

AU - Piralla, Antonio

AU - Pariani, Elena

AU - Rovida, Francesca

AU - Campanini, Giulia

AU - Muzzi, Alba

AU - Emmi, Vincenzo

AU - Iotti, Giorgio A.

AU - Pesenti, Antonio

AU - Conaldi, Pier Giulio

AU - Zanetti, Alessandro

AU - Baldanti, Fausto

PY - 2011/12/14

Y1 - 2011/12/14

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