Seizure outcome in surgically treated drug-resistant mesial temporal lobe epilepsy based on the recent histopathological classifications: Clinical article

Marco Giulioni, Gianluca Marucci, Matteo Martinoni, Lilia Volpi, Patrizia Riguzzi, Anna Federica Marliani, Francesca Bisulli, Paolo Tinuper, Carlo Alberto Tassinari, Roberto Michelucci, Guido Rubboli

Research output: Contribution to journalArticle

Abstract

Object. The study was performed to investigate the relation between seizure outcome after surgical treatment of mesial temporal lobe epilepsy (MTLE) and pathological findings, classified according to the recently proposed classifications of mesial temporal sclerosis (MTS), granule cell pathology (GCP), focal cortical dysplasia (FCD) and epilepsy-associated low-grade tumors (ELGT). Methods. The authors analyzed data obtained in 120 consecutive cases involving patients presenting with drugresistant MTLE, who underwent tailored anteromesial temporal lobe resection, and correlated seizure outcome with pathological findings. They identified 5 histopathological groups: Group 1-ELGT, alone or associated with other lesions (30 cases); Group 2-isolated FCD (17 cases); Group 3-MTS, with or without GCP (28 cases); Group 4- MTS associated with FCD, with or without GCP (37 cases); Group 5-other lesions (8 cases). Results. Engel Class I outcome was observed in 83% of patients with ELGT (Class IA in 63%); in 59% of patients with isolated FCD, with FCD Type II showing a better prognosis than FCD Type I; in 82% of patients with isolated MTS (Class IA in 50%), with MTS Type 1a and MTS Type 1b showing a better prognosis than MTS Type 2 and patients with MTS and GCP having better postsurgical results than those with MTS without GCP. Engel Class I outcome was also achieved in 84% of patients with FCD associated with MTS (Engel Class IA in 62%); also in this group MTS 1a and MTS 1b associated with FCD showed a better prognosis than FCD associated with MTS 2. Finally, Engel Class I was also achieved in 2 patients with vascular malformation and in 1 with a temporal pole encephalocele. Conclusions. Patients with MTLE and ELGT, MTS, or MTS associated with FCD showed the best postsurgical seizure outcome (Engel Class I in more than 80% of cases), whereas only 63% of patients with isolated FCD achieved the same type of outcome. Interestingly, the analysis of seizure outcome in histopathological subtypes of FCD and of MTS showed different prognoses in the different pathological subgroups, with worse outcomes for atypical MTS, absence of GCP, and isolated FCD Type I.

Original languageEnglish
Pages (from-to)37-47
Number of pages11
JournalJournal of Neurosurgery
Volume119
Issue number1
DOIs
Publication statusPublished - Jul 2013

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Keywords

  • Cortical dysplasia
  • Epilepsy surgery
  • Glioneuronal tumor
  • Granule cell pathology
  • Hippocampal sclerosis
  • Low-grade tumor
  • Mesial temporal lobe epilepsy
  • Seizure outcome

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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