Seizure susceptibility and epileptogenesis are decreased in transgenic rats overexpressing neuropeptide Y

A. Vezzani, M. Michalkiewicz, T. Michalkiewicz, D. Moneta, T. Ravizza, C. Richichi, M. Aliprandi, F. Mulé, L. Pirona, M. Gobbi, C. Schwarzer, G. Sperk

Research output: Contribution to journalArticle

Abstract

Functional studies in epileptic tissue indicate that neuropeptide Y and some of its peptide analogs potently inhibit seizure activity. We investigated seizure susceptibility in transgenic rats overexpressing the rat neuropeptide Y gene under the control of its natural promoter. Seizures were induced in adult transgenic male rats and their wild-type littermates by i.c.v. injection of 0.3 μg kainic acid or by electrical kindling of the dorsal hippocampus. Transgenic rats showed a significant reduction in the number and duration of electroencephalographic seizures induced by kainate by 30% and 55% respectively (P

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalNeuroscience
Volume110
Issue number2
DOIs
Publication statusPublished - Mar 12 2002

Keywords

  • Anticonvulsant
  • Epilepsy
  • Hippocampus
  • Kainic acid
  • Kindling
  • Limbic system

ASJC Scopus subject areas

  • Neuroscience(all)

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    Vezzani, A., Michalkiewicz, M., Michalkiewicz, T., Moneta, D., Ravizza, T., Richichi, C., Aliprandi, M., Mulé, F., Pirona, L., Gobbi, M., Schwarzer, C., & Sperk, G. (2002). Seizure susceptibility and epileptogenesis are decreased in transgenic rats overexpressing neuropeptide Y. Neuroscience, 110(2), 237-243. https://doi.org/10.1016/S0306-4522(01)00581-4