Seizure-triggered Takotsubo syndrome rarely causes SUDEP

Josef Finsterer, Anna Bersano

Research output: Contribution to journalArticlepeer-review

Abstract

Since almost 20 y it is known that seizures may trigger Takotsubo syndrome (TTS). Since then it has been repeatedly proposed that TTS could be the cause of sudden unexpected death in epilepsy (SUDEP). A review of the so far reported cases of seizure-triggered TTS was carried out to see how often seizure-triggered TTS is fatal. Altogether 59 papers were identified which reported altogether 74 patients with seizure-triggered TTS. Age was reported in 70 patients and ranged from 18 to 82 y. Gender was reported in 70 cases and was female in 60 cases (86%). The type of triggering seizure was reported in 47 cases. In 28 patients (60%) the trigger was a generalized tonic clonic seizure, in 15 cases (32%) a generalized status epilepticus, and in 3 cases a complex partial seizure. The outcome was mentioned in 63 of the 74 patients. Full recovery was reported in 61 cases (97%), incomplete recovery in none of the patients, and a fatal outcome in 2 patients (3%). Fatalities are rare in patients experiencing seizure-triggered TTS. This is why seizure-triggered TTS does not seem to play a major role in the pathogenesis of SUDEP.

Original languageEnglish
Pages (from-to)84-87
Number of pages4
JournalSeizure
Volume31
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • Cardiomyopathy
  • Complication
  • Epilepsy
  • Heart failure
  • Seizure
  • Sudden unexpected death in epilepsy
  • Takotsubo

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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