Seizures and epilepsy in Sotos syndrome: Analysis of 19 Caucasian patients with long-term follow-up

Francesco Nicita; Martino Ruggieri; Agata Polizzi; Laura Mauceri; Vincenzo Salpietro; Silvana Briuglia; Laura Papetti; Fabiana Ursitti; Salvatore Grosso; Luigi Tarani; Maria Segni; Salvatore Savasta; Pasquale Parisi; Alberto Verrotti; Alberto Spalice

doi:10.1111/j.1528-1167.2012.03418.x

Seizures and epilepsy in Sotos syndrome: Analysis of 19 Caucasian patients with long-term follow-up

Francesco Nicita, Martino Ruggieri, Agata Polizzi, Laura Mauceri, Vincenzo Salpietro, Silvana Briuglia, Laura Papetti, Fabiana Ursitti, Salvatore Grosso, Luigi Tarani, Maria Segni, Salvatore Savasta, Pasquale Parisi, Alberto Verrotti, Alberto Spalice

Research output: Contribution to journal › Article › peer-review

Abstract

Sotos syndrome (SS) is an overgrowth syndrome characterized by typical facial appearance, learning disability, and macrocephaly as cardinal diagnostic features. Febrile (FS) and afebrile seizures are reported in 9-50% of cases. There is no evidence that patients with SS and FS later develop epilepsy, and no studies have investigated the electroclinical features and the long-term outcome in epileptic SS patients. The authors report a series of 19 SS patients with FS and/or epilepsy during childhood and a long-term follow-up. More than half of FS evolved to epilepsy. Temporal lobe seizures were recorded in 40% of patients with SS. Seizures were easy to control with common antiepileptic drugs in almost all patients. A careful neurologic evaluation is useful for SS patients, since seizures are an important finding among people with this overgrowth syndrome.

Original language	English
Journal	Epilepsia
Volume	53
Issue number	6
DOIs	https://doi.org/10.1111/j.1528-1167.2012.03418.x
Publication status	Published - Jun 2012

Keywords

Cerebral gigantism
Epilepsy
Overgrowth syndrome
Seizures
Sotos syndrome

ASJC Scopus subject areas

Clinical Neurology
Neurology

Access to Document

10.1111/j.1528-1167.2012.03418.x

Fingerprint Dive into the research topics of 'Seizures and epilepsy in Sotos syndrome: Analysis of 19 Caucasian patients with long-term follow-up'. Together they form a unique fingerprint.

Cite this

Nicita, F., Ruggieri, M., Polizzi, A., Mauceri, L., Salpietro, V., Briuglia, S., Papetti, L., Ursitti, F., Grosso, S., Tarani, L., Segni, M., Savasta, S., Parisi, P., Verrotti, A., & Spalice, A. (2012). Seizures and epilepsy in Sotos syndrome: Analysis of 19 Caucasian patients with long-term follow-up. Epilepsia, 53(6). https://doi.org/10.1111/j.1528-1167.2012.03418.x

Seizures and epilepsy in Sotos syndrome : Analysis of 19 Caucasian patients with long-term follow-up. / Nicita, Francesco; Ruggieri, Martino; Polizzi, Agata; Mauceri, Laura; Salpietro, Vincenzo; Briuglia, Silvana; Papetti, Laura; Ursitti, Fabiana; Grosso, Salvatore; Tarani, Luigi; Segni, Maria; Savasta, Salvatore; Parisi, Pasquale; Verrotti, Alberto; Spalice, Alberto.

In: Epilepsia, Vol. 53, No. 6, 06.2012.

Research output: Contribution to journal › Article › peer-review

Nicita, Francesco ; Ruggieri, Martino ; Polizzi, Agata ; Mauceri, Laura ; Salpietro, Vincenzo ; Briuglia, Silvana ; Papetti, Laura ; Ursitti, Fabiana ; Grosso, Salvatore ; Tarani, Luigi ; Segni, Maria ; Savasta, Salvatore ; Parisi, Pasquale ; Verrotti, Alberto ; Spalice, Alberto. / Seizures and epilepsy in Sotos syndrome : Analysis of 19 Caucasian patients with long-term follow-up. In: Epilepsia. 2012 ; Vol. 53, No. 6.

@article{f3c7d532f39a435497063c0731ed9dde,

title = "Seizures and epilepsy in Sotos syndrome: Analysis of 19 Caucasian patients with long-term follow-up",

abstract = "Sotos syndrome (SS) is an overgrowth syndrome characterized by typical facial appearance, learning disability, and macrocephaly as cardinal diagnostic features. Febrile (FS) and afebrile seizures are reported in 9-50% of cases. There is no evidence that patients with SS and FS later develop epilepsy, and no studies have investigated the electroclinical features and the long-term outcome in epileptic SS patients. The authors report a series of 19 SS patients with FS and/or epilepsy during childhood and a long-term follow-up. More than half of FS evolved to epilepsy. Temporal lobe seizures were recorded in 40% of patients with SS. Seizures were easy to control with common antiepileptic drugs in almost all patients. A careful neurologic evaluation is useful for SS patients, since seizures are an important finding among people with this overgrowth syndrome.",

keywords = "Cerebral gigantism, Epilepsy, Overgrowth syndrome, Seizures, Sotos syndrome",

author = "Francesco Nicita and Martino Ruggieri and Agata Polizzi and Laura Mauceri and Vincenzo Salpietro and Silvana Briuglia and Laura Papetti and Fabiana Ursitti and Salvatore Grosso and Luigi Tarani and Maria Segni and Salvatore Savasta and Pasquale Parisi and Alberto Verrotti and Alberto Spalice",

year = "2012",

month = jun,

doi = "10.1111/j.1528-1167.2012.03418.x",

language = "English",

volume = "53",

journal = "Epilepsia",

issn = "0013-9580",

publisher = "Blackwell Publishing Inc.",

number = "6",

}

TY - JOUR

T1 - Seizures and epilepsy in Sotos syndrome

T2 - Analysis of 19 Caucasian patients with long-term follow-up

AU - Nicita, Francesco

AU - Ruggieri, Martino

AU - Polizzi, Agata

AU - Mauceri, Laura

AU - Salpietro, Vincenzo

AU - Briuglia, Silvana

AU - Papetti, Laura

AU - Ursitti, Fabiana

AU - Grosso, Salvatore

AU - Tarani, Luigi

AU - Segni, Maria

AU - Savasta, Salvatore

AU - Parisi, Pasquale

AU - Verrotti, Alberto

AU - Spalice, Alberto

PY - 2012/6

Y1 - 2012/6

N2 - Sotos syndrome (SS) is an overgrowth syndrome characterized by typical facial appearance, learning disability, and macrocephaly as cardinal diagnostic features. Febrile (FS) and afebrile seizures are reported in 9-50% of cases. There is no evidence that patients with SS and FS later develop epilepsy, and no studies have investigated the electroclinical features and the long-term outcome in epileptic SS patients. The authors report a series of 19 SS patients with FS and/or epilepsy during childhood and a long-term follow-up. More than half of FS evolved to epilepsy. Temporal lobe seizures were recorded in 40% of patients with SS. Seizures were easy to control with common antiepileptic drugs in almost all patients. A careful neurologic evaluation is useful for SS patients, since seizures are an important finding among people with this overgrowth syndrome.

AB - Sotos syndrome (SS) is an overgrowth syndrome characterized by typical facial appearance, learning disability, and macrocephaly as cardinal diagnostic features. Febrile (FS) and afebrile seizures are reported in 9-50% of cases. There is no evidence that patients with SS and FS later develop epilepsy, and no studies have investigated the electroclinical features and the long-term outcome in epileptic SS patients. The authors report a series of 19 SS patients with FS and/or epilepsy during childhood and a long-term follow-up. More than half of FS evolved to epilepsy. Temporal lobe seizures were recorded in 40% of patients with SS. Seizures were easy to control with common antiepileptic drugs in almost all patients. A careful neurologic evaluation is useful for SS patients, since seizures are an important finding among people with this overgrowth syndrome.

KW - Cerebral gigantism

KW - Epilepsy

KW - Overgrowth syndrome

KW - Seizures

KW - Sotos syndrome

UR - http://www.scopus.com/inward/record.url?scp=84861826012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861826012&partnerID=8YFLogxK

U2 - 10.1111/j.1528-1167.2012.03418.x

DO - 10.1111/j.1528-1167.2012.03418.x

M3 - Article

C2 - 22352460

AN - SCOPUS:84861826012

VL - 53

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - 6

ER -