Abstract
Sotos syndrome (SS) is an overgrowth syndrome characterized by typical facial appearance, learning disability, and macrocephaly as cardinal diagnostic features. Febrile (FS) and afebrile seizures are reported in 9-50% of cases. There is no evidence that patients with SS and FS later develop epilepsy, and no studies have investigated the electroclinical features and the long-term outcome in epileptic SS patients. The authors report a series of 19 SS patients with FS and/or epilepsy during childhood and a long-term follow-up. More than half of FS evolved to epilepsy. Temporal lobe seizures were recorded in 40% of patients with SS. Seizures were easy to control with common antiepileptic drugs in almost all patients. A careful neurologic evaluation is useful for SS patients, since seizures are an important finding among people with this overgrowth syndrome.
Original language | English |
---|---|
Journal | Epilepsia |
Volume | 53 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2012 |
Keywords
- Cerebral gigantism
- Epilepsy
- Overgrowth syndrome
- Seizures
- Sotos syndrome
ASJC Scopus subject areas
- Clinical Neurology
- Neurology