Seizures in Chiari I malformation: A clinical and electroencephalographic study

Maurizio Elia, Roberto Biondi, Vito Sofia, Sebastiano A. Musumeci, Raffaele Ferri, Giuseppe Capovilla, Paolo Curatolo

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Seven subjects with Chiari I malformations and seizures (four males, three females; age range 11 years, 7 months to 36 years; mean, 22.28 ± 7.58 years; median, 21) were identified in four different centers from among a group of 10 patients. Our aim was to analyze clinical and electroencephalographic characteristics of seizures in this etiologically homogeneous group of patients. Most of the seizures were of the complex partial type, and paroxysmal abnormalities were mainly localized over the frontal and temporal regions. The course of the epilepsy was rather benign, with complete control of seizures in four patients and an important reduction in frequency in the remaining three subjects. Other cortical alterations are not usually associated with the typical abnormalities of the posterior fossa in Chiari I malformation; thus, it is possible to hypothesize that cerebral microdysgenesis or, alternatively, a cerebellar dysfunction could underlie epileptogenesis in these patients.

Original languageEnglish
Pages (from-to)446-450
Number of pages5
JournalJournal of Child Neurology
Issue number7
Publication statusPublished - Jul 1999

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health


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