Seizures in Klinefelter's syndrome: A clinical and EEG study of five patients

M. Elia, S. A. Musumeci, R. Ferri, C. Scuderi, S. Del Gracco, M. C. Stefanini

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In this study, we report the cases of five unrelated patients with Klinefelter's syndrome and seizures or EEG epileptiform abnomalities; the karyotype was 47,XXY in four, and 47,XXY/46,XX in one. They were aged 13-25 years and followed up both clinically and by means of EEG. Two of the patients had epilepsy, one had only one isolated generalized tonic-clonic seizure, one had febrile convulsions and one presented focal epileptiform EEG abnormalities without seizures. In two of the patients, it was possible to classify the epilepsy (childhood epilepsy with occipital paroxysms and cryptogenic or symptomatic generalized epilepsy). Although the electroclinical patterns appeared to be rather heterogeneous in our patients, it is possible to infer the relative good evolution of seizures in Klinefelter's syndrome.

Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalItalian Journal of Neurological Sciences
Issue number3
Publication statusPublished - Apr 1995


  • brain imaging
  • epilepsy
  • epileptiform EEG abnormalities
  • genetics
  • Klinefelter's syndrome

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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