TY - JOUR
T1 - Seizures in Klinefelter's syndrome
T2 - A clinical and EEG study of five patients
AU - Elia, M.
AU - Musumeci, S. A.
AU - Ferri, R.
AU - Scuderi, C.
AU - Del Gracco, S.
AU - Stefanini, M. C.
PY - 1995/4
Y1 - 1995/4
N2 - In this study, we report the cases of five unrelated patients with Klinefelter's syndrome and seizures or EEG epileptiform abnomalities; the karyotype was 47,XXY in four, and 47,XXY/46,XX in one. They were aged 13-25 years and followed up both clinically and by means of EEG. Two of the patients had epilepsy, one had only one isolated generalized tonic-clonic seizure, one had febrile convulsions and one presented focal epileptiform EEG abnormalities without seizures. In two of the patients, it was possible to classify the epilepsy (childhood epilepsy with occipital paroxysms and cryptogenic or symptomatic generalized epilepsy). Although the electroclinical patterns appeared to be rather heterogeneous in our patients, it is possible to infer the relative good evolution of seizures in Klinefelter's syndrome.
AB - In this study, we report the cases of five unrelated patients with Klinefelter's syndrome and seizures or EEG epileptiform abnomalities; the karyotype was 47,XXY in four, and 47,XXY/46,XX in one. They were aged 13-25 years and followed up both clinically and by means of EEG. Two of the patients had epilepsy, one had only one isolated generalized tonic-clonic seizure, one had febrile convulsions and one presented focal epileptiform EEG abnormalities without seizures. In two of the patients, it was possible to classify the epilepsy (childhood epilepsy with occipital paroxysms and cryptogenic or symptomatic generalized epilepsy). Although the electroclinical patterns appeared to be rather heterogeneous in our patients, it is possible to infer the relative good evolution of seizures in Klinefelter's syndrome.
KW - brain imaging
KW - epilepsy
KW - epileptiform EEG abnormalities
KW - genetics
KW - Klinefelter's syndrome
UR - http://www.scopus.com/inward/record.url?scp=0029015015&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029015015&partnerID=8YFLogxK
U2 - 10.1007/BF02282994
DO - 10.1007/BF02282994
M3 - Article
C2 - 7591675
AN - SCOPUS:0029015015
VL - 16
SP - 231
EP - 238
JO - Italian Journal of Neurological Sciences
JF - Italian Journal of Neurological Sciences
SN - 0392-0461
IS - 3
ER -