TY - JOUR
T1 - Seizures in patients with trisomy 21
AU - Romano, C.
AU - Tine, A.
AU - Fazio, G.
AU - Rizzo, R.
AU - Colognola, R. M.
AU - Sorge, G.
AU - Bergonzi, P.
AU - Pavone, L.
PY - 1990
Y1 - 1990
N2 - We report on the incidence of seizures in 113 patients with Down Syndrome (DS), 43 coming from the OASI Institute for Research on Mental Retardation and Brain Aging, Troina, and 70 from the outpatient clinic of the Department of Pediatrics, University of Catania. We obtained the following results: 15 (13.2%) patients had seizures; 6 (5.3%) febrile seizures (FS) and 9 (7.9%) afebrile seizures (aFS). Among the latter group 2 patients had generalized tonic-clonic seizures, 3 partial complex seizures, and 4 infantile spasms. The seizures appeared early in life. Only 2 adult patients had seizures. These results suggest that patients with DS show a higher incidence of FS and of aFS than non-DS individuals. Seizures in DS may be an epiphenomenon of the neurological abnormalities, both anatomical and functional, usually observed in these patients.
AB - We report on the incidence of seizures in 113 patients with Down Syndrome (DS), 43 coming from the OASI Institute for Research on Mental Retardation and Brain Aging, Troina, and 70 from the outpatient clinic of the Department of Pediatrics, University of Catania. We obtained the following results: 15 (13.2%) patients had seizures; 6 (5.3%) febrile seizures (FS) and 9 (7.9%) afebrile seizures (aFS). Among the latter group 2 patients had generalized tonic-clonic seizures, 3 partial complex seizures, and 4 infantile spasms. The seizures appeared early in life. Only 2 adult patients had seizures. These results suggest that patients with DS show a higher incidence of FS and of aFS than non-DS individuals. Seizures in DS may be an epiphenomenon of the neurological abnormalities, both anatomical and functional, usually observed in these patients.
KW - afebrile seizures trisomy-21
KW - febrile seizures
UR - http://www.scopus.com/inward/record.url?scp=0025654653&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025654653&partnerID=8YFLogxK
M3 - Article
C2 - 2149964
AN - SCOPUS:0025654653
SP - 298
EP - 300
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
SN - 1552-4825
IS - SUPPL. 7
ER -