Seizures in patients with trisomy 21

C. Romano, A. Tine, G. Fazio, R. Rizzo, R. M. Colognola, G. Sorge, P. Bergonzi, L. Pavone

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We report on the incidence of seizures in 113 patients with Down Syndrome (DS), 43 coming from the OASI Institute for Research on Mental Retardation and Brain Aging, Troina, and 70 from the outpatient clinic of the Department of Pediatrics, University of Catania. We obtained the following results: 15 (13.2%) patients had seizures; 6 (5.3%) febrile seizures (FS) and 9 (7.9%) afebrile seizures (aFS). Among the latter group 2 patients had generalized tonic-clonic seizures, 3 partial complex seizures, and 4 infantile spasms. The seizures appeared early in life. Only 2 adult patients had seizures. These results suggest that patients with DS show a higher incidence of FS and of aFS than non-DS individuals. Seizures in DS may be an epiphenomenon of the neurological abnormalities, both anatomical and functional, usually observed in these patients.

Original languageEnglish
Pages (from-to)298-300
Number of pages3
JournalAmerican Journal of Medical Genetics
Issue numberSUPPL. 7
Publication statusPublished - 1990


  • afebrile seizures trisomy-21
  • febrile seizures

ASJC Scopus subject areas

  • Genetics(clinical)
  • Medicine(all)


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