Crisi epilettiche indotte dall'assunzione di leflunomide in pazienti in terapia con Carbamazepina

Translated title of the contribution: Seizures induced by leflunomide medication in patients on Carbamazepine therapy

V. Belcastro, G. Gorgone, D. Italiano, L. R. Pisani, M. Napoli, G. Badolato, G. Oteri, G. F. Bagnato, F. Pisani

Research output: Contribution to journalArticle

Abstract

Three women suffering from focal seizures and treated with CBZ monotherapy showed an unespected increase in seizure frequency/seizure reappearance following treatment with the antirheumatic drug leflunomide. This event was associated to a reduction in blood levels of CBZ of 31.6-47.3% (7.5-11.2 μg/ml to 4.6-5.9 μg/ml), after 4-10 days of leflunomide co-medication. This finding might be due to a leflunomide induction of CBZ metabolism, an intereraction at the absorption level, a patient non-compliance or, even, an epileptogenic effect of leflunomide.

Original languageItalian
Pages (from-to)191-192
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number129-130
Publication statusPublished - 2005

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leflunomide
Carbamazepine
Seizures
Antirheumatic Agents
Therapeutics
Patient Compliance

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Belcastro, V., Gorgone, G., Italiano, D., Pisani, L. R., Napoli, M., Badolato, G., ... Pisani, F. (2005). Crisi epilettiche indotte dall'assunzione di leflunomide in pazienti in terapia con Carbamazepina. Bollettino - Lega Italiana contro l'Epilessia, (129-130), 191-192.

Crisi epilettiche indotte dall'assunzione di leflunomide in pazienti in terapia con Carbamazepina. / Belcastro, V.; Gorgone, G.; Italiano, D.; Pisani, L. R.; Napoli, M.; Badolato, G.; Oteri, G.; Bagnato, G. F.; Pisani, F.

In: Bollettino - Lega Italiana contro l'Epilessia, No. 129-130, 2005, p. 191-192.

Research output: Contribution to journalArticle

Belcastro, V, Gorgone, G, Italiano, D, Pisani, LR, Napoli, M, Badolato, G, Oteri, G, Bagnato, GF & Pisani, F 2005, 'Crisi epilettiche indotte dall'assunzione di leflunomide in pazienti in terapia con Carbamazepina', Bollettino - Lega Italiana contro l'Epilessia, no. 129-130, pp. 191-192.
Belcastro V, Gorgone G, Italiano D, Pisani LR, Napoli M, Badolato G et al. Crisi epilettiche indotte dall'assunzione di leflunomide in pazienti in terapia con Carbamazepina. Bollettino - Lega Italiana contro l'Epilessia. 2005;(129-130):191-192.
Belcastro, V. ; Gorgone, G. ; Italiano, D. ; Pisani, L. R. ; Napoli, M. ; Badolato, G. ; Oteri, G. ; Bagnato, G. F. ; Pisani, F. / Crisi epilettiche indotte dall'assunzione di leflunomide in pazienti in terapia con Carbamazepina. In: Bollettino - Lega Italiana contro l'Epilessia. 2005 ; No. 129-130. pp. 191-192.
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