Three women suffering from focal seizures and treated with CBZ monotherapy showed an unespected increase in seizure frequency/seizure reappearance following treatment with the antirheumatic drug leflunomide. This event was associated to a reduction in blood levels of CBZ of 31.6-47.3% (7.5-11.2 μg/ml to 4.6-5.9 μg/ml), after 4-10 days of leflunomide co-medication. This finding might be due to a leflunomide induction of CBZ metabolism, an intereraction at the absorption level, a patient non-compliance or, even, an epileptogenic effect of leflunomide.
|Translated title of the contribution||Seizures induced by leflunomide medication in patients on Carbamazepine therapy|
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 2005|
ASJC Scopus subject areas
- Clinical Neurology