Abstract
Three women suffering from focal seizures and treated with CBZ monotherapy showed an unespected increase in seizure frequency/seizure reappearance following treatment with the antirheumatic drug leflunomide. This event was associated to a reduction in blood levels of CBZ of 31.6-47.3% (7.5-11.2 μg/ml to 4.6-5.9 μg/ml), after 4-10 days of leflunomide co-medication. This finding might be due to a leflunomide induction of CBZ metabolism, an intereraction at the absorption level, a patient non-compliance or, even, an epileptogenic effect of leflunomide.
| Original language | Italian |
|---|---|
| Pages (from-to) | 191-192 |
| Number of pages | 2 |
| Journal | Bollettino - Lega Italiana contro l'Epilessia |
| Issue number | 129-130 |
| Publication status | Published - 2005 |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Crisi epilettiche indotte dall'assunzione di leflunomide in pazienti in terapia con Carbamazepina. / Belcastro, V.; Gorgone, G.; Italiano, D.; Pisani, L. R.; Napoli, M.; Badolato, G.; Oteri, G.; Bagnato, G. F.; Pisani, F.
In: Bollettino - Lega Italiana contro l'Epilessia, No. 129-130, 2005, p. 191-192.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Crisi epilettiche indotte dall'assunzione di leflunomide in pazienti in terapia con Carbamazepina
AU - Belcastro, V.
AU - Gorgone, G.
AU - Italiano, D.
AU - Pisani, L. R.
AU - Napoli, M.
AU - Badolato, G.
AU - Oteri, G.
AU - Bagnato, G. F.
AU - Pisani, F.
PY - 2005
Y1 - 2005
N2 - Three women suffering from focal seizures and treated with CBZ monotherapy showed an unespected increase in seizure frequency/seizure reappearance following treatment with the antirheumatic drug leflunomide. This event was associated to a reduction in blood levels of CBZ of 31.6-47.3% (7.5-11.2 μg/ml to 4.6-5.9 μg/ml), after 4-10 days of leflunomide co-medication. This finding might be due to a leflunomide induction of CBZ metabolism, an intereraction at the absorption level, a patient non-compliance or, even, an epileptogenic effect of leflunomide.
AB - Three women suffering from focal seizures and treated with CBZ monotherapy showed an unespected increase in seizure frequency/seizure reappearance following treatment with the antirheumatic drug leflunomide. This event was associated to a reduction in blood levels of CBZ of 31.6-47.3% (7.5-11.2 μg/ml to 4.6-5.9 μg/ml), after 4-10 days of leflunomide co-medication. This finding might be due to a leflunomide induction of CBZ metabolism, an intereraction at the absorption level, a patient non-compliance or, even, an epileptogenic effect of leflunomide.
KW - Carbamazepine
KW - Drug interactions
KW - Leflunomide
KW - Non-compliance
UR - http://www.scopus.com/inward/record.url?scp=33645212268&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645212268&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:33645212268
SP - 191
EP - 192
JO - Bollettino - Lega Italiana contro l'Epilessia
JF - Bollettino - Lega Italiana contro l'Epilessia
SN - 0394-560X
IS - 129-130
ER -