Crisi epilettiche indotte dall'assunzione di leflunomide in pazienti in terapia con Carbamazepina

V. Belcastro; G. Gorgone; D. Italiano; L. R. Pisani; M. Napoli; G. Badolato; G. Oteri; G. F. Bagnato; F. Pisani

Crisi epilettiche indotte dall'assunzione di leflunomide in pazienti in terapia con Carbamazepina

Translated title of the contribution: Seizures induced by leflunomide medication in patients on Carbamazepine therapy

V. Belcastro, G. Gorgone, D. Italiano, L. R. Pisani, M. Napoli, G. Badolato, G. Oteri, G. F. Bagnato, F. Pisani

IRCCS Centro Neurolesi "Bonino Pulejo"

Research output: Contribution to journal › Article › peer-review

Abstract

Three women suffering from focal seizures and treated with CBZ monotherapy showed an unespected increase in seizure frequency/seizure reappearance following treatment with the antirheumatic drug leflunomide. This event was associated to a reduction in blood levels of CBZ of 31.6-47.3% (7.5-11.2 μg/ml to 4.6-5.9 μg/ml), after 4-10 days of leflunomide co-medication. This finding might be due to a leflunomide induction of CBZ metabolism, an intereraction at the absorption level, a patient non-compliance or, even, an epileptogenic effect of leflunomide.

Translated title of the contribution	Seizures induced by leflunomide medication in patients on Carbamazepine therapy
Original language	Italian
Pages (from-to)	191-192
Number of pages	2
Journal	Bollettino - Lega Italiana contro l'Epilessia
Issue number	129-130
Publication status	Published - 2005

ASJC Scopus subject areas

Clinical Neurology

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Crisi epilettiche indotte dall'assunzione di leflunomide in pazienti in terapia con Carbamazepina. / Belcastro, V.; Gorgone, G.; Italiano, D.; Pisani, L. R.; Napoli, M.; Badolato, G.; Oteri, G.; Bagnato, G. F.; Pisani, F.

In: Bollettino - Lega Italiana contro l'Epilessia, No. 129-130, 2005, p. 191-192.

Research output: Contribution to journal › Article › peer-review

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title = "Crisi epilettiche indotte dall'assunzione di leflunomide in pazienti in terapia con Carbamazepina",

abstract = "Three women suffering from focal seizures and treated with CBZ monotherapy showed an unespected increase in seizure frequency/seizure reappearance following treatment with the antirheumatic drug leflunomide. This event was associated to a reduction in blood levels of CBZ of 31.6-47.3% (7.5-11.2 μg/ml to 4.6-5.9 μg/ml), after 4-10 days of leflunomide co-medication. This finding might be due to a leflunomide induction of CBZ metabolism, an intereraction at the absorption level, a patient non-compliance or, even, an epileptogenic effect of leflunomide.",

keywords = "Carbamazepine, Drug interactions, Leflunomide, Non-compliance",

author = "V. Belcastro and G. Gorgone and D. Italiano and Pisani, {L. R.} and M. Napoli and G. Badolato and G. Oteri and Bagnato, {G. F.} and F. Pisani",

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AU - Belcastro, V.

AU - Gorgone, G.

AU - Italiano, D.

AU - Pisani, L. R.

AU - Napoli, M.

AU - Badolato, G.

AU - Oteri, G.

AU - Bagnato, G. F.

AU - Pisani, F.

PY - 2005

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N2 - Three women suffering from focal seizures and treated with CBZ monotherapy showed an unespected increase in seizure frequency/seizure reappearance following treatment with the antirheumatic drug leflunomide. This event was associated to a reduction in blood levels of CBZ of 31.6-47.3% (7.5-11.2 μg/ml to 4.6-5.9 μg/ml), after 4-10 days of leflunomide co-medication. This finding might be due to a leflunomide induction of CBZ metabolism, an intereraction at the absorption level, a patient non-compliance or, even, an epileptogenic effect of leflunomide.

AB - Three women suffering from focal seizures and treated with CBZ monotherapy showed an unespected increase in seizure frequency/seizure reappearance following treatment with the antirheumatic drug leflunomide. This event was associated to a reduction in blood levels of CBZ of 31.6-47.3% (7.5-11.2 μg/ml to 4.6-5.9 μg/ml), after 4-10 days of leflunomide co-medication. This finding might be due to a leflunomide induction of CBZ metabolism, an intereraction at the absorption level, a patient non-compliance or, even, an epileptogenic effect of leflunomide.

KW - Carbamazepine

KW - Drug interactions

KW - Leflunomide

KW - Non-compliance

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