Selected micronutrient intake and thyroid carcinoma risk

Barbara D'Avanzo, Elaine Ron, Carlo La Vecchia, Silvia Franceschi, Eva Negri, Regina Ziegler

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

BACKGROUND. Protection from thyroid carcinoma due to certain dietary factors was suggested by several studies, but the findings were relatively inconsistent. The role of micronutrients has not yet been systematically analyzed. To investigate the relationship between micronutrient intake and thyroid carcinoma risk, the authors used data from a case-control study conducted in northern Italy between 1986 and 1992. METHODS. The study included 399 incident, histologically confirmed thyroid carcinoma cases and 617 controls admitted to the hospital for acute, nonneoplastic, nonhormone- related diseases. RESULTS. Retinol intake showed a direct association with thyroid carcinoma risk, with odds ratios (ORs) of 1.39 (95% confidence interval [CI], 0.9-2.0) in the third quartile of consumption and 1.52 (95% CI, 1.0-2.3) in the highest quartile, whereas beta-carotene had an inverse relationship, with ORs of 0.63 (95% CI, 0.4-0.9) in the third quartile of consumption and 0.58 (95% CI, 0.4- 0.9) in the highest quartile compared with the lowest quartile. Some protection was observed for measures of vitamin C intake (with an OR of 0.72) and vitamin E (with an OR of 0.67) for the highest quartile of consumption, although the estimates were not statistically significant, and were reduced after adjustment for beta- carotene intake. No clear pattern in risk appeared for vitamin D, folate, calcium, thiamin, or riboflavin. The inverse relationship between beta- carotene and thyroid carcinoma was observed in both papillary and follicular carcinomas. CONCLUSIONS. In this study, a significant inverse association between beta-carotene and thyroid carcinoma was observed, and some protection against thyroid carcinoma from vitamins C and E was also suggested.

Original languageEnglish
Pages (from-to)2186-2192
Number of pages7
JournalCancer
Volume79
Issue number11
DOIs
Publication statusPublished - Jun 1 1997

Fingerprint

Micronutrients
Thyroid Neoplasms
beta Carotene
Odds Ratio
Confidence Intervals
Vitamin E
Ascorbic Acid
Carcinoma, Papillary, Follicular
Riboflavin
Thiamine
Vitamin A
Folic Acid
Vitamin D
Italy
Case-Control Studies
Calcium

Keywords

  • case-control study
  • histologic type
  • micronutrients
  • thyroid carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Selected micronutrient intake and thyroid carcinoma risk. / D'Avanzo, Barbara; Ron, Elaine; La Vecchia, Carlo; Franceschi, Silvia; Negri, Eva; Ziegler, Regina.

In: Cancer, Vol. 79, No. 11, 01.06.1997, p. 2186-2192.

Research output: Contribution to journalArticle

D'Avanzo, B, Ron, E, La Vecchia, C, Franceschi, S, Negri, E & Ziegler, R 1997, 'Selected micronutrient intake and thyroid carcinoma risk', Cancer, vol. 79, no. 11, pp. 2186-2192. https://doi.org/10.1002/(SICI)1097-0142(19970601)79:11<2186::AID-CNCR17>3.0.CO;2-S
D'Avanzo, Barbara ; Ron, Elaine ; La Vecchia, Carlo ; Franceschi, Silvia ; Negri, Eva ; Ziegler, Regina. / Selected micronutrient intake and thyroid carcinoma risk. In: Cancer. 1997 ; Vol. 79, No. 11. pp. 2186-2192.
@article{c0fe12f798b742ffada1a258f3f04e6a,
title = "Selected micronutrient intake and thyroid carcinoma risk",
abstract = "BACKGROUND. Protection from thyroid carcinoma due to certain dietary factors was suggested by several studies, but the findings were relatively inconsistent. The role of micronutrients has not yet been systematically analyzed. To investigate the relationship between micronutrient intake and thyroid carcinoma risk, the authors used data from a case-control study conducted in northern Italy between 1986 and 1992. METHODS. The study included 399 incident, histologically confirmed thyroid carcinoma cases and 617 controls admitted to the hospital for acute, nonneoplastic, nonhormone- related diseases. RESULTS. Retinol intake showed a direct association with thyroid carcinoma risk, with odds ratios (ORs) of 1.39 (95{\%} confidence interval [CI], 0.9-2.0) in the third quartile of consumption and 1.52 (95{\%} CI, 1.0-2.3) in the highest quartile, whereas beta-carotene had an inverse relationship, with ORs of 0.63 (95{\%} CI, 0.4-0.9) in the third quartile of consumption and 0.58 (95{\%} CI, 0.4- 0.9) in the highest quartile compared with the lowest quartile. Some protection was observed for measures of vitamin C intake (with an OR of 0.72) and vitamin E (with an OR of 0.67) for the highest quartile of consumption, although the estimates were not statistically significant, and were reduced after adjustment for beta- carotene intake. No clear pattern in risk appeared for vitamin D, folate, calcium, thiamin, or riboflavin. The inverse relationship between beta- carotene and thyroid carcinoma was observed in both papillary and follicular carcinomas. CONCLUSIONS. In this study, a significant inverse association between beta-carotene and thyroid carcinoma was observed, and some protection against thyroid carcinoma from vitamins C and E was also suggested.",
keywords = "case-control study, histologic type, micronutrients, thyroid carcinoma",
author = "Barbara D'Avanzo and Elaine Ron and {La Vecchia}, Carlo and Silvia Franceschi and Eva Negri and Regina Ziegler",
year = "1997",
month = "6",
day = "1",
doi = "10.1002/(SICI)1097-0142(19970601)79:11<2186::AID-CNCR17>3.0.CO;2-S",
language = "English",
volume = "79",
pages = "2186--2192",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "11",

}

TY - JOUR

T1 - Selected micronutrient intake and thyroid carcinoma risk

AU - D'Avanzo, Barbara

AU - Ron, Elaine

AU - La Vecchia, Carlo

AU - Franceschi, Silvia

AU - Negri, Eva

AU - Ziegler, Regina

PY - 1997/6/1

Y1 - 1997/6/1

N2 - BACKGROUND. Protection from thyroid carcinoma due to certain dietary factors was suggested by several studies, but the findings were relatively inconsistent. The role of micronutrients has not yet been systematically analyzed. To investigate the relationship between micronutrient intake and thyroid carcinoma risk, the authors used data from a case-control study conducted in northern Italy between 1986 and 1992. METHODS. The study included 399 incident, histologically confirmed thyroid carcinoma cases and 617 controls admitted to the hospital for acute, nonneoplastic, nonhormone- related diseases. RESULTS. Retinol intake showed a direct association with thyroid carcinoma risk, with odds ratios (ORs) of 1.39 (95% confidence interval [CI], 0.9-2.0) in the third quartile of consumption and 1.52 (95% CI, 1.0-2.3) in the highest quartile, whereas beta-carotene had an inverse relationship, with ORs of 0.63 (95% CI, 0.4-0.9) in the third quartile of consumption and 0.58 (95% CI, 0.4- 0.9) in the highest quartile compared with the lowest quartile. Some protection was observed for measures of vitamin C intake (with an OR of 0.72) and vitamin E (with an OR of 0.67) for the highest quartile of consumption, although the estimates were not statistically significant, and were reduced after adjustment for beta- carotene intake. No clear pattern in risk appeared for vitamin D, folate, calcium, thiamin, or riboflavin. The inverse relationship between beta- carotene and thyroid carcinoma was observed in both papillary and follicular carcinomas. CONCLUSIONS. In this study, a significant inverse association between beta-carotene and thyroid carcinoma was observed, and some protection against thyroid carcinoma from vitamins C and E was also suggested.

AB - BACKGROUND. Protection from thyroid carcinoma due to certain dietary factors was suggested by several studies, but the findings were relatively inconsistent. The role of micronutrients has not yet been systematically analyzed. To investigate the relationship between micronutrient intake and thyroid carcinoma risk, the authors used data from a case-control study conducted in northern Italy between 1986 and 1992. METHODS. The study included 399 incident, histologically confirmed thyroid carcinoma cases and 617 controls admitted to the hospital for acute, nonneoplastic, nonhormone- related diseases. RESULTS. Retinol intake showed a direct association with thyroid carcinoma risk, with odds ratios (ORs) of 1.39 (95% confidence interval [CI], 0.9-2.0) in the third quartile of consumption and 1.52 (95% CI, 1.0-2.3) in the highest quartile, whereas beta-carotene had an inverse relationship, with ORs of 0.63 (95% CI, 0.4-0.9) in the third quartile of consumption and 0.58 (95% CI, 0.4- 0.9) in the highest quartile compared with the lowest quartile. Some protection was observed for measures of vitamin C intake (with an OR of 0.72) and vitamin E (with an OR of 0.67) for the highest quartile of consumption, although the estimates were not statistically significant, and were reduced after adjustment for beta- carotene intake. No clear pattern in risk appeared for vitamin D, folate, calcium, thiamin, or riboflavin. The inverse relationship between beta- carotene and thyroid carcinoma was observed in both papillary and follicular carcinomas. CONCLUSIONS. In this study, a significant inverse association between beta-carotene and thyroid carcinoma was observed, and some protection against thyroid carcinoma from vitamins C and E was also suggested.

KW - case-control study

KW - histologic type

KW - micronutrients

KW - thyroid carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0030988187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030988187&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-0142(19970601)79:11<2186::AID-CNCR17>3.0.CO;2-S

DO - 10.1002/(SICI)1097-0142(19970601)79:11<2186::AID-CNCR17>3.0.CO;2-S

M3 - Article

C2 - 9179066

AN - SCOPUS:0030988187

VL - 79

SP - 2186

EP - 2192

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 11

ER -