Selecting multimodal therapy for rhabdomyosarcoma

Iyad Sultan, Andrea Ferrari

Research output: Contribution to journalArticle

Abstract

Rhabdomyosarcoma is a typical tumor of childhood, characterized by a high grade of malignancy, local invasiveness and a marked propensity to metastasize, but also a generally good response to chemotherapy and radiotherapy. Multimodal therapy is essential to cure rhabdomyosarcoma patients, but different uses of surgery, radiotherapy and chemotherapy, and their intensity, need to be selected and modulated to different patient risk groups. This article attempts to give an account of the current treatment options, the open and debated issues and the potential novel strategies for the near future.

Original languageEnglish
Pages (from-to)1285-1301
Number of pages17
JournalExpert Review of Anticancer Therapy
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 2010

Keywords

  • chemotherapy
  • multidisciplinary
  • pediatric
  • prognosis
  • radiotherapy
  • rhabdomyosarcoma
  • soft-tissue sarcoma
  • stratification
  • surgery

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

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