Selection of biologically active peptides by phage display of random peptide libraries

Riccardo Cortese, Paolo Monaci, Alessandra Luzzago, Claudia Santini, Fabrizia Bartoli, Irene Cortese, Paola Fortugno, Giovanni Galfrè, Alfredo Nicosia, Franco Felici

Research output: Contribution to journalArticlepeer-review

Abstract

Random peptide libraries displayed on phage are used as a source of peptides for epitope mapping, for the identification of critical amino acids responsible for protein-protein interactions and as leads for the discovery of new therapeutics. Efficient and simple procedures have been devised to select peptides binding to purified proteins, to monoclonal and polyclonal antibodies and to cell surfaces in vivo and in vitro.

Original languageEnglish
Pages (from-to)616-621
Number of pages6
JournalCurrent Opinion in Biotechnology
Volume7
Issue number6
DOIs
Publication statusPublished - Dec 1996

ASJC Scopus subject areas

  • Biotechnology

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