Selection of optimal hemodynamic response function for FMRI analysis on acute stroke patients

Silva Francesca Storti, E. Formaggio, A. Bertoldo, P. Manganotti, A. Fiaschi, G. M. Toffolo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

In this study we developed and tested a procedure designed to choose optimum hemodynamic response function (HRF) models for identifying changes in cerebral hemodynamics after delivery of median-nerve electrical stimulation in patients with acute stroke. Seventeen acute stroke patients underwent functional magnetic resonance imaging (fMRI) to investigate hemodynamic responses in the contralateral and ipsilateral primary somatosensory area (SI) after median-nerve electrical stimulation. fMRI activation images were acquired with a 3 T MR scanner. When the optimal model was applied after electrical stimulation, hemodynamic responses in the contralateral SI cortex differed in the 17 patients and showed wide intersubject variability. We analyzed the fMRI data by a novel software SOHIA (Selection of Optimal HRF and Image Analysis) developed in our laboratory and implemented in Matlab. Our results indicate some heterogeneity in the optimal HRF of our 17 acute stroke patients. Therefore the use of the same model in all subjects is inappropriate, and may results in bias in localization and/or extension of the activation map. Based on Akaike information criterion (AIC) for each subject SOHIA allows us to select the best HRF among available HRFs of Brain Voyager QX (BVQX) and Statistical Parametric Mapping 5 (SPM5) software.

Original languageEnglish
Title of host publicationIFMBE Proceedings
Pages253-256
Number of pages4
Volume25
Edition4
DOIs
Publication statusPublished - 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
CountryGermany
CityMunich
Period9/7/099/12/09

Fingerprint

Hemodynamics
Image analysis
Chemical activation
Brain
Magnetic Resonance Imaging

Keywords

  • Acute stroke
  • Akaike information criterion
  • fMRI
  • Hemodynamic response function
  • Median-nerve stimulation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Storti, S. F., Formaggio, E., Bertoldo, A., Manganotti, P., Fiaschi, A., & Toffolo, G. M. (2009). Selection of optimal hemodynamic response function for FMRI analysis on acute stroke patients. In IFMBE Proceedings (4 ed., Vol. 25, pp. 253-256) https://doi.org/10.1007/978-3-642-03882-2-67

Selection of optimal hemodynamic response function for FMRI analysis on acute stroke patients. / Storti, Silva Francesca; Formaggio, E.; Bertoldo, A.; Manganotti, P.; Fiaschi, A.; Toffolo, G. M.

IFMBE Proceedings. Vol. 25 4. ed. 2009. p. 253-256.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Storti, SF, Formaggio, E, Bertoldo, A, Manganotti, P, Fiaschi, A & Toffolo, GM 2009, Selection of optimal hemodynamic response function for FMRI analysis on acute stroke patients. in IFMBE Proceedings. 4 edn, vol. 25, pp. 253-256, World Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics, Munich, Germany, 9/7/09. https://doi.org/10.1007/978-3-642-03882-2-67
Storti SF, Formaggio E, Bertoldo A, Manganotti P, Fiaschi A, Toffolo GM. Selection of optimal hemodynamic response function for FMRI analysis on acute stroke patients. In IFMBE Proceedings. 4 ed. Vol. 25. 2009. p. 253-256 https://doi.org/10.1007/978-3-642-03882-2-67
Storti, Silva Francesca ; Formaggio, E. ; Bertoldo, A. ; Manganotti, P. ; Fiaschi, A. ; Toffolo, G. M. / Selection of optimal hemodynamic response function for FMRI analysis on acute stroke patients. IFMBE Proceedings. Vol. 25 4. ed. 2009. pp. 253-256
@inproceedings{c54c415754db45caadb7540e520fb174,
title = "Selection of optimal hemodynamic response function for FMRI analysis on acute stroke patients",
abstract = "In this study we developed and tested a procedure designed to choose optimum hemodynamic response function (HRF) models for identifying changes in cerebral hemodynamics after delivery of median-nerve electrical stimulation in patients with acute stroke. Seventeen acute stroke patients underwent functional magnetic resonance imaging (fMRI) to investigate hemodynamic responses in the contralateral and ipsilateral primary somatosensory area (SI) after median-nerve electrical stimulation. fMRI activation images were acquired with a 3 T MR scanner. When the optimal model was applied after electrical stimulation, hemodynamic responses in the contralateral SI cortex differed in the 17 patients and showed wide intersubject variability. We analyzed the fMRI data by a novel software SOHIA (Selection of Optimal HRF and Image Analysis) developed in our laboratory and implemented in Matlab. Our results indicate some heterogeneity in the optimal HRF of our 17 acute stroke patients. Therefore the use of the same model in all subjects is inappropriate, and may results in bias in localization and/or extension of the activation map. Based on Akaike information criterion (AIC) for each subject SOHIA allows us to select the best HRF among available HRFs of Brain Voyager QX (BVQX) and Statistical Parametric Mapping 5 (SPM5) software.",
keywords = "Acute stroke, Akaike information criterion, fMRI, Hemodynamic response function, Median-nerve stimulation",
author = "Storti, {Silva Francesca} and E. Formaggio and A. Bertoldo and P. Manganotti and A. Fiaschi and Toffolo, {G. M.}",
year = "2009",
doi = "10.1007/978-3-642-03882-2-67",
language = "English",
isbn = "9783642038815",
volume = "25",
pages = "253--256",
booktitle = "IFMBE Proceedings",
edition = "4",

}

TY - GEN

T1 - Selection of optimal hemodynamic response function for FMRI analysis on acute stroke patients

AU - Storti, Silva Francesca

AU - Formaggio, E.

AU - Bertoldo, A.

AU - Manganotti, P.

AU - Fiaschi, A.

AU - Toffolo, G. M.

PY - 2009

Y1 - 2009

N2 - In this study we developed and tested a procedure designed to choose optimum hemodynamic response function (HRF) models for identifying changes in cerebral hemodynamics after delivery of median-nerve electrical stimulation in patients with acute stroke. Seventeen acute stroke patients underwent functional magnetic resonance imaging (fMRI) to investigate hemodynamic responses in the contralateral and ipsilateral primary somatosensory area (SI) after median-nerve electrical stimulation. fMRI activation images were acquired with a 3 T MR scanner. When the optimal model was applied after electrical stimulation, hemodynamic responses in the contralateral SI cortex differed in the 17 patients and showed wide intersubject variability. We analyzed the fMRI data by a novel software SOHIA (Selection of Optimal HRF and Image Analysis) developed in our laboratory and implemented in Matlab. Our results indicate some heterogeneity in the optimal HRF of our 17 acute stroke patients. Therefore the use of the same model in all subjects is inappropriate, and may results in bias in localization and/or extension of the activation map. Based on Akaike information criterion (AIC) for each subject SOHIA allows us to select the best HRF among available HRFs of Brain Voyager QX (BVQX) and Statistical Parametric Mapping 5 (SPM5) software.

AB - In this study we developed and tested a procedure designed to choose optimum hemodynamic response function (HRF) models for identifying changes in cerebral hemodynamics after delivery of median-nerve electrical stimulation in patients with acute stroke. Seventeen acute stroke patients underwent functional magnetic resonance imaging (fMRI) to investigate hemodynamic responses in the contralateral and ipsilateral primary somatosensory area (SI) after median-nerve electrical stimulation. fMRI activation images were acquired with a 3 T MR scanner. When the optimal model was applied after electrical stimulation, hemodynamic responses in the contralateral SI cortex differed in the 17 patients and showed wide intersubject variability. We analyzed the fMRI data by a novel software SOHIA (Selection of Optimal HRF and Image Analysis) developed in our laboratory and implemented in Matlab. Our results indicate some heterogeneity in the optimal HRF of our 17 acute stroke patients. Therefore the use of the same model in all subjects is inappropriate, and may results in bias in localization and/or extension of the activation map. Based on Akaike information criterion (AIC) for each subject SOHIA allows us to select the best HRF among available HRFs of Brain Voyager QX (BVQX) and Statistical Parametric Mapping 5 (SPM5) software.

KW - Acute stroke

KW - Akaike information criterion

KW - fMRI

KW - Hemodynamic response function

KW - Median-nerve stimulation

UR - http://www.scopus.com/inward/record.url?scp=77950107934&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950107934&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-03882-2-67

DO - 10.1007/978-3-642-03882-2-67

M3 - Conference contribution

AN - SCOPUS:77950107934

SN - 9783642038815

VL - 25

SP - 253

EP - 256

BT - IFMBE Proceedings

ER -