TY - JOUR
T1 - Selection of patients with high risk endometrial cancer for surgical staging according to the evaluation of pre- And intraoperative risk factors
AU - Sala, Paolo
AU - Moran, Eva
AU - Paolucci, Roberta
AU - Menoni, Stefania
AU - Fulcheri, Ezio
AU - Costantini, Sergio
AU - Valenzano Menada, Mario
PY - 2016/2/1
Y1 - 2016/2/1
N2 - BacKground: The aim of this paper was to assess the accuracy of frozen sections histological examination and preoperative CA-125 to select patients with high risk endometrial cancer. Methods: We reviewed women with type I endometrial cancer treated from January 2011 through January 2013 at the same university hospital. Preoperative CA-125 and intraoperative frozen sections were analyzed to select patients at high risk for metastases, according to Mayo Clinic algorithm. All patients underwent hysterectomy with bilateral adnexectomy. High risk patients underwent complete surgical staging. Respectively, we compared the accuracy of CA-125, frozen sections, and an algorithm combining Ca-125 plus frozen sections, with permanent sections histology as positive control. χ2 test, Landis and Koch kappa statistics (k), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were determined for each variable. Results: One hundred seventy-two women were included. CA-125 levels, using 8.3 U/ml as cut-off value, showed 63.4% sensitivity, 51.6% specificity, 84.7% PPV, 25.0% NPV, 61.1% accuracy, and a low kappa statistics (k=0.106, P
AB - BacKground: The aim of this paper was to assess the accuracy of frozen sections histological examination and preoperative CA-125 to select patients with high risk endometrial cancer. Methods: We reviewed women with type I endometrial cancer treated from January 2011 through January 2013 at the same university hospital. Preoperative CA-125 and intraoperative frozen sections were analyzed to select patients at high risk for metastases, according to Mayo Clinic algorithm. All patients underwent hysterectomy with bilateral adnexectomy. High risk patients underwent complete surgical staging. Respectively, we compared the accuracy of CA-125, frozen sections, and an algorithm combining Ca-125 plus frozen sections, with permanent sections histology as positive control. χ2 test, Landis and Koch kappa statistics (k), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were determined for each variable. Results: One hundred seventy-two women were included. CA-125 levels, using 8.3 U/ml as cut-off value, showed 63.4% sensitivity, 51.6% specificity, 84.7% PPV, 25.0% NPV, 61.1% accuracy, and a low kappa statistics (k=0.106, P
KW - CA-125 antigen
KW - Endometrial neoplasms
KW - Frozen sections
KW - Lymph node excision
KW - Lymphatic metastasis risk
UR - http://www.scopus.com/inward/record.url?scp=84964336812&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964336812&partnerID=8YFLogxK
M3 - Article
VL - 68
SP - 21
EP - 28
JO - Minerva Ginecologica
JF - Minerva Ginecologica
SN - 0026-4784
IS - 1
ER -