Selection of potential predictors of worsening heart failure: Rational and design of the SELENE HF study

Luigi Padeletti, Giovanni Luca Botto, Antonio Curnis, Ermenegildo De Ruvod, Antonio DâOnofrio, Edoardo Gronda, Renato Pietro Ricci, Antonello Vado, Gabriele Zanotto, Massimo Zecchin, Xenia Antoniou, Alessio Gargaro

Research output: Contribution to journalArticle

Abstract

Background Heart failure is a leading cause of hospitalization and a significant medical burden in our society. Implantable medical devices are nowadays established therapies inheart failure patients that not only providecardiac resynchronization therapy (CRT) and implantable cardioverter defibrillators (ICDs) therapy but are also able to continuously and remotely monitor diagnostic information of various physiologic parameters. The value of combining individual diagnostic variables to predict worsening of heart failure is still largely unclear but could eventually become a valuable tool towards a better heart failure management. Methods SELENE HF (Selection of potential predictors of worsening Heart Failure) is an observational, multicentre study designed to prospectively collect follow-up and home monitoring data trends from a population of individuals with ICDs with or without resynchronization therapy (CRT-D), to document heart failure hospitalizations and deaths and to correlate these events with Home Monitoring data in order to identify the combination with the greatest sensitivity and specificity in predicting heart failure events. The purpose of this study is to describe the design of the study focusing on the Heart Failure Predicting model and statistical approach that will be used to analyse the data. Conclusion The results of the SELENE HF study could help to select and define potential predictors of worsening heart failure in patients with remotely monitored ICD or CRT-D devices.

Original languageEnglish
Pages (from-to)782-789
Number of pages8
JournalJournal of Cardiovascular Medicine
Volume16
Issue number11
DOIs
Publication statusPublished - Nov 11 2015

    Fingerprint

Keywords

  • Cardiac resynchronisation therapy
  • Heart failure
  • Implantable cardioverter defibrillators
  • Remote monitoring

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Padeletti, L., Botto, G. L., Curnis, A., De Ruvod, E., DâOnofrio, A., Gronda, E., Ricci, R. P., Vado, A., Zanotto, G., Zecchin, M., Antoniou, X., & Gargaro, A. (2015). Selection of potential predictors of worsening heart failure: Rational and design of the SELENE HF study. Journal of Cardiovascular Medicine, 16(11), 782-789. https://doi.org/10.2459/JCM.0000000000000171