Selection strategies for newly registered blood donors in European countries

R.W. Lieshout-Krikke, D. Domanovic, W. De Kort, W. Mayr, G.M. Liumbruno, S. Pupella, J. Kurz, F. Knutson, S. MacLennan, G. Folléa

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Two selection strategies for newly-registered blood donors are available: A singlevisit selection called the standard selection procedure (SSP), and a two-stage selection named predonation and donation screening (PDS). This study reviews the selection strategies for newly-registered donors currently applied in European countries. Material and methods. We collected data on donor selection procedures, blood donation, laboratory screening and HIV, HCV and HBV positive donors/donations from 2010 to 2013 in 30 European countries by using questionnaires. We grouped the countries according to the applied selection strategy, and for each country, we calculated the 4-year prevalence of confirmed positive results indicating the presence of overall and recent HIV, HCV and HBV infections among first-time and repeat donations and among newly-registered donors. Results. Most of the 24 countries (80%) apply the SSP strategy for selection of newly-registered donors. Twenty-two countries (73.3%) employ a nucleic acid amplification testing in addition to the mandatory serological screening. The survey confirms a higher overall prevalence of HIV, HCV and HBV infections among first-time donations and newly-registered donors than among repeat donations. In contrast, the prevalence of recently acquired HIV and HCV infections was lower among first-time donations and newly-registered donors than among repeat donations, but higher for recent HBV infections (6.7/105 vs 2.6/105 in the SSP setting and 4.3/105 vs 0.5/105 in one country using PDS). The relatively low numbers of infected donors selected by PDS impeded accurate assessment of the prevalence of recent infections in first-time donations. Discussion. The data from European countries provide inconclusive evidence that applying PDS reduces the risk of donations being made in the diagnostic window of first-time donors. The impact of PDS on the risk of window-period donations and blood donor management needs further investigation. © 2017 SIMTI Servizi Srl.
Original languageEnglish
Pages (from-to)495-501
Number of pages7
JournalBlood Transfusion
Volume15
Issue number6
DOIs
Publication statusPublished - 2017

Keywords

  • Donors
  • Infectious diseases
  • Screening
  • Selection
  • Article
  • Austria
  • Belgium
  • blood donor
  • Bulgaria
  • cohort analysis
  • Croatia
  • Cyprus
  • Czech Republic
  • Denmark
  • donor selection
  • England
  • Estonia
  • Europe
  • Finland
  • France
  • Germany
  • hepatitis B
  • hepatitis C
  • human
  • Human immunodeficiency virus
  • Human immunodeficiency virus infection
  • Hungary
  • Ireland
  • Italy
  • laboratory test
  • Latvia
  • Lithuania
  • Luxembourg
  • major clinical study
  • Malta
  • Netherlands
  • Northern Ireland
  • Norway
  • nucleic acid amplification
  • Poland
  • Portugal
  • prevalence
  • questionnaire
  • register
  • Romania
  • screening
  • Slovakia
  • Slovenia
  • Spain
  • Sweden
  • Switzerland

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