Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia

Maura Boldrini, L. Del Pace, G. P A Placidi, J. Keilp, S. P. Ellis, S. Signori, G. F. Placidi, S. F. Cappa

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Objective: Visual-spatial and executive functions deficits have been reported in obsessive-compulsive disorder (OCD). We investigated their specificity comparing cognitive function in OCD, panic disorder with agoraphobia (PD/A) and controls by a comprehensive neuropsychological battery. Method: Fifty-five subjects (25 OCD, 15 PD/A, 15 controls) without current depressive episode underwent structured clinical interview for DSM-IV, Yale-Brown Obsessive Compulsive Scale, Hamilton Anxiety Rating Scale, Hamilton Depression Rating Scale. Neuropsychological battery assessed: executive functions, visual discrimination, spatial memory and learning, verbal memory, general intellectual functioning. Results: OCD showed controlled fluency, visual-spatial construction, learning and memory deficits; PD/A spatial learning impairment. OCD was discriminated from PD/A and controls by three tests scores, predicting group membership for 76.4% of the cases. Conclusion: Visual-constructive and controlled fluency deficits seem specific in OCD, while the spatial learning deficit, shared with PD patients, may not be disorder-specific, but anxiety-related. Results support the proposed ventral frontal-striatal circuit involvement in OCD.

Original languageEnglish
Pages (from-to)150-158
Number of pages9
JournalActa Psychiatrica Scandinavica
Volume111
Issue number2
DOIs
Publication statusPublished - Feb 2005

Fingerprint

Agoraphobia
Panic Disorder
Obsessive-Compulsive Disorder
Executive Function
Corpus Striatum
Memory Disorders
Anxiety Disorders
Diagnostic and Statistical Manual of Mental Disorders
Cognition
Anxiety
Interviews
Depression
Spatial Learning

Keywords

  • Basal ganglia
  • Neuropsychological test
  • Obsessive-compulsive disorder
  • Panic disorder
  • Prefrontal cortex
  • Temporal lobe

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Boldrini, M., Del Pace, L., Placidi, G. P. A., Keilp, J., Ellis, S. P., Signori, S., ... Cappa, S. F. (2005). Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. Acta Psychiatrica Scandinavica, 111(2), 150-158. https://doi.org/10.1111/j.1600-0447.2004.00247.x

Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. / Boldrini, Maura; Del Pace, L.; Placidi, G. P A; Keilp, J.; Ellis, S. P.; Signori, S.; Placidi, G. F.; Cappa, S. F.

In: Acta Psychiatrica Scandinavica, Vol. 111, No. 2, 02.2005, p. 150-158.

Research output: Contribution to journalArticle

Boldrini, M, Del Pace, L, Placidi, GPA, Keilp, J, Ellis, SP, Signori, S, Placidi, GF & Cappa, SF 2005, 'Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia', Acta Psychiatrica Scandinavica, vol. 111, no. 2, pp. 150-158. https://doi.org/10.1111/j.1600-0447.2004.00247.x
Boldrini, Maura ; Del Pace, L. ; Placidi, G. P A ; Keilp, J. ; Ellis, S. P. ; Signori, S. ; Placidi, G. F. ; Cappa, S. F. / Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. In: Acta Psychiatrica Scandinavica. 2005 ; Vol. 111, No. 2. pp. 150-158.
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