Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

Valentina Zuco, Rosanna Supino, Sabina C. Righetti, Loredana Cleris, Edoardo Marchesi, Carlo Gambacorti-Passerini, Franca Formelli

Research output: Contribution to journalArticlepeer-review

Abstract

Betulinic acid is a triterpene with selective cytotoxicity against melanoma, neuroectodermal and malignant brain tumor cell lines. In this study the betulinic acid activity was evaluated, in comparison with doxorubicin, on different human neoplastic and non-neoplastic cell lines and on proliferating normal lymphocytes. Growth inhibition was evident in all the neoplastic cell lines independently on p53 status and histotype. Antiproliferative activity of betulinic acid was related to a cytotoxic effect on two p53 wild-type and on one p53 mutant cell lines and to a cytostatic effect on one p53 mutant melanoma clone. At the same concentrations, normal cells were unaffected indicating a selective effect of this agent. A cytotoxic activity of doxorubicin was evident on all the tested systems. In vivo experiments, performed on one of these cell lines, confirmed the antineoplastic activity of this drug. These data support further preclinical studies of betulinic acid not confined to melanoma and neuroectodermal tumors independently of p53 status.

Original languageEnglish
Pages (from-to)17-25
Number of pages9
JournalCancer Letters
Volume175
Issue number1
DOIs
Publication statusPublished - Jan 10 2002

Keywords

  • Antitumor activity
  • Betulinic acid
  • Cytotoxic/cytostatic effects
  • Normal cell
  • Tumor cell

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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