Selective D-1 dopamine receptor agonist effects in hyperkinetic extrapyramidal disorders

A. Braun, M. M. Mouradian, E. Mohr, G. Fabbrini, T. N. Chase

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The motor and cognitive effects of a selective D-1 dopamine receptor agonist, SKF 39393, were assessed in patients with Huntington's disease, Gilles de la Tourette's syndrome, tardive dyskinesia, and torsion dystonia, using a double-blind placebo-controlled design. Over daily doses ranging from 3.2 to 32 mg/kg and treatment intervals extending from one to seven weeks, no consistent changes could be discerned. The contribution of D-1 receptor mediated mechanisms to the pathophysiology of hyperkinetic extrapyramidal disorders remains uncertain.

Original languageEnglish
Pages (from-to)631-635
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume52
Issue number5
Publication statusPublished - 1989

Fingerprint

Basal Ganglia Diseases
Dopamine Agonists
Dystonia Musculorum Deformans
Tourette Syndrome
Huntington Disease
Placebos
Tardive Dyskinesia
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Selective D-1 dopamine receptor agonist effects in hyperkinetic extrapyramidal disorders. / Braun, A.; Mouradian, M. M.; Mohr, E.; Fabbrini, G.; Chase, T. N.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 52, No. 5, 1989, p. 631-635.

Research output: Contribution to journalArticle

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