Selective defect of a T helper subpopulation in severe combined immunodeficiency

Luisa Businco, F. Pandolfi, P. Rossi, D. Del Principe, M. Fiorilli, I. Quinti, F. Aiuti

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The case of an infant female aged 1 month with severe infections, failure to thrive, and skin erythroderma is reported. Immunological studies demonstrated a severe combined immunodeficiency (SCID) with B cells and normal serum IgM levels. Studies of T-cell subpopulations showed a defect of a subset of T helper cells. Possible pathogenetic mechanisms are discussed.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalJournal of Clinical Immunology
Volume1
Issue number2
DOIs
Publication statusPublished - Apr 1981

Fingerprint

Exfoliative Dermatitis
Severe Combined Immunodeficiency
Failure to Thrive
Helper-Inducer T-Lymphocytes
Immunoglobulin M
B-Lymphocytes
T-Lymphocytes
Skin
Infection
Serum

Keywords

  • Severe combined immunodeficiency
  • T helper-cell subpopulations
  • T-cell subpopulations

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Businco, L., Pandolfi, F., Rossi, P., Del Principe, D., Fiorilli, M., Quinti, I., & Aiuti, F. (1981). Selective defect of a T helper subpopulation in severe combined immunodeficiency. Journal of Clinical Immunology, 1(2), 125-130. https://doi.org/10.1007/BF00915390

Selective defect of a T helper subpopulation in severe combined immunodeficiency. / Businco, Luisa; Pandolfi, F.; Rossi, P.; Del Principe, D.; Fiorilli, M.; Quinti, I.; Aiuti, F.

In: Journal of Clinical Immunology, Vol. 1, No. 2, 04.1981, p. 125-130.

Research output: Contribution to journalArticle

Businco, L, Pandolfi, F, Rossi, P, Del Principe, D, Fiorilli, M, Quinti, I & Aiuti, F 1981, 'Selective defect of a T helper subpopulation in severe combined immunodeficiency', Journal of Clinical Immunology, vol. 1, no. 2, pp. 125-130. https://doi.org/10.1007/BF00915390
Businco, Luisa ; Pandolfi, F. ; Rossi, P. ; Del Principe, D. ; Fiorilli, M. ; Quinti, I. ; Aiuti, F. / Selective defect of a T helper subpopulation in severe combined immunodeficiency. In: Journal of Clinical Immunology. 1981 ; Vol. 1, No. 2. pp. 125-130.
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