Selective defect of a T helper subpopulation in severe combined immunodeficiency

Luisa Businco, F. Pandolfi, P. Rossi, D. Del Principe, M. Fiorilli, I. Quinti, F. Aiuti

Research output: Contribution to journalArticlepeer-review


The case of an infant female aged 1 month with severe infections, failure to thrive, and skin erythroderma is reported. Immunological studies demonstrated a severe combined immunodeficiency (SCID) with B cells and normal serum IgM levels. Studies of T-cell subpopulations showed a defect of a subset of T helper cells. Possible pathogenetic mechanisms are discussed.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalJournal of Clinical Immunology
Issue number2
Publication statusPublished - Apr 1981


  • Severe combined immunodeficiency
  • T helper-cell subpopulations
  • T-cell subpopulations

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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