Selective depletion of the OKT 4+ 4B4+ subset in lymph nodes from HIV+ patients

P. De Paoli, A. Carbone, S. Battistin, M. Crovatto, N. Arreghini, G. Santini

Research output: Contribution to journalArticlepeer-review

Abstract

We have used 4B4 and 2H4 monoclonal antibodies in conjunction with OKT4 to quantify T cell subsets in lymph node suspensions from human immunodeficiency virus (HIV) positive subjects with lymphadenopathy syndrome. The data indicate that the reduced OKT 4:OKT 8 ratio was due to a depletion of the OKT 4+ 4B4+ subset. In contrast, there were no differences compared to reactive controls, considering the OKT 8+ subpopulation. These alterations may be related to the immunological deficiency associated with HIV infection.

Original languageEnglish
Pages (from-to)71-73
Number of pages3
JournalImmunology Letters
Volume16
Issue number1
DOIs
Publication statusPublished - 1987

Keywords

  • 4B4
  • Human immunodeficiency virus
  • Lymph nodes
  • Lymphocytes
  • OKT 4

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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