Selective detection of 13C-containing metabolites by 1H double-resonance BLISS sequence

S. Capuani, L. Mancini, B. Maraviglia

Research output: Contribution to journalArticlepeer-review

Abstract

Recently there has been a great deal of interest in double-resonance methods capable to enhance the detection sensitivity of less sensitive nuclei such as 13C in liquid system, in order to study brain metabolism noninvasively. The main disadvantage of the existing 1H-observed/13C-editing double resonance techniques, based on intermolecular short-range J-coupling interaction, is the nontotal proton solvent elimination. The indirect 13C-editing and spatial localisation in 10 mM solution of enriched glucose in water, was obtained in our laboratory by means of the BLISS (bilinear and linear interaction spin-selection and solvent suppression) sequence with total solvent elimination. The sensitivity gain and the water suppression are here theoretically calculated and experimentally verified.

Original languageEnglish
Pages (from-to)383-391
Number of pages9
JournalApplied Magnetic Resonance
Volume15
Issue number3-4
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Spectroscopy
  • Atomic and Molecular Physics, and Optics

Fingerprint Dive into the research topics of 'Selective detection of 13C-containing metabolites by 1H double-resonance BLISS sequence'. Together they form a unique fingerprint.

Cite this