Selective detection of 13C-containing metabolites by 1H double-resonance BLISS sequence

S. Capuani; L. Mancini; B. Maraviglia

Selective detection of 13C-containing metabolites by 1H double-resonance BLISS sequence

S. Capuani, L. Mancini, B. Maraviglia

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Recently there has been a great deal of interest in double-resonance methods capable to enhance the detection sensitivity of less sensitive nuclei such as ¹³C in liquid system, in order to study brain metabolism noninvasively. The main disadvantage of the existing ¹H-observed/¹³C-editing double resonance techniques, based on intermolecular short-range J-coupling interaction, is the nontotal proton solvent elimination. The indirect ¹³C-editing and spatial localisation in 10 mM solution of enriched glucose in water, was obtained in our laboratory by means of the BLISS (bilinear and linear interaction spin-selection and solvent suppression) sequence with total solvent elimination. The sensitivity gain and the water suppression are here theoretically calculated and experimentally verified.

Original language	English
Pages (from-to)	383-391
Number of pages	9
Journal	Applied Magnetic Resonance
Volume	15
Issue number	3-4
Publication status	Published - 1998

ASJC Scopus subject areas

Spectroscopy
Atomic and Molecular Physics, and Optics

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title = "Selective detection of 13C-containing metabolites by 1H double-resonance BLISS sequence",

abstract = "Recently there has been a great deal of interest in double-resonance methods capable to enhance the detection sensitivity of less sensitive nuclei such as 13C in liquid system, in order to study brain metabolism noninvasively. The main disadvantage of the existing 1H-observed/13C-editing double resonance techniques, based on intermolecular short-range J-coupling interaction, is the nontotal proton solvent elimination. The indirect 13C-editing and spatial localisation in 10 mM solution of enriched glucose in water, was obtained in our laboratory by means of the BLISS (bilinear and linear interaction spin-selection and solvent suppression) sequence with total solvent elimination. The sensitivity gain and the water suppression are here theoretically calculated and experimentally verified.",

author = "S. Capuani and L. Mancini and B. Maraviglia",

year = "1998",

language = "English",

volume = "15",

pages = "383--391",

journal = "Applied Magnetic Resonance",

issn = "0937-9347",

publisher = "Springer Wien",

number = "3-4",

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T1 - Selective detection of 13C-containing metabolites by 1H double-resonance BLISS sequence

AU - Capuani, S.

AU - Mancini, L.

AU - Maraviglia, B.

PY - 1998

Y1 - 1998

N2 - Recently there has been a great deal of interest in double-resonance methods capable to enhance the detection sensitivity of less sensitive nuclei such as 13C in liquid system, in order to study brain metabolism noninvasively. The main disadvantage of the existing 1H-observed/13C-editing double resonance techniques, based on intermolecular short-range J-coupling interaction, is the nontotal proton solvent elimination. The indirect 13C-editing and spatial localisation in 10 mM solution of enriched glucose in water, was obtained in our laboratory by means of the BLISS (bilinear and linear interaction spin-selection and solvent suppression) sequence with total solvent elimination. The sensitivity gain and the water suppression are here theoretically calculated and experimentally verified.

AB - Recently there has been a great deal of interest in double-resonance methods capable to enhance the detection sensitivity of less sensitive nuclei such as 13C in liquid system, in order to study brain metabolism noninvasively. The main disadvantage of the existing 1H-observed/13C-editing double resonance techniques, based on intermolecular short-range J-coupling interaction, is the nontotal proton solvent elimination. The indirect 13C-editing and spatial localisation in 10 mM solution of enriched glucose in water, was obtained in our laboratory by means of the BLISS (bilinear and linear interaction spin-selection and solvent suppression) sequence with total solvent elimination. The sensitivity gain and the water suppression are here theoretically calculated and experimentally verified.

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